Wang Ningqun, Huang Xiaobo, Chen Wenqiang, Zhang Xiaomei, Zhang Yongsheng, Chen Yujing
a Department of Traditional Chinese Medicine , Xuanwu Hospital of Capital Medical University , Beijing , China.
b Department of Respiratory Medicine , Dongfang Hospital of Beijing University of Chinese Medicine , Beijing , China.
J Asthma. 2017 Dec;54(10):1073-1084. doi: 10.1080/02770903.2017.1291674. Epub 2017 Feb 21.
To assess the acceptability, reliability, validity, and responsiveness of the Chinese Asthma Quality of Life Questionnaire (C-AQLQ) in a sample of Chinese asthma patients.
The C-AQLQ and Short Form 36 Health Survey (SF-36) scales were administered to patients at baseline and 3 months later. Asthma severity condition and lung function were evaluated. Necessary data were gathered to assess the psychometric properties such as the feasibility, internal consistency, test-retest reliability, structural validity, discriminant validity, convergent validity, and responsiveness of the C-AQLQ.
One hundred and thirty-seven patients completed the investigation. The Cronbach's alpha coefficient for the total scale was 0.96. Factor analysis yielded five factors that generally corresponded to the five proposed subscales. Patients with mild asthma reported higher scores than patients with moderate/severe asthma on all subscales other than environmental stimuli. Lung function measurement and the asthma severity score correlated significantly with domains of the C-AQOL but with fewer domains of the SF-36. The questionnaire detected within-subject changes in patients' asthma status during follow-up.
Results indicated preliminary support that the C-AQLQ is a reliable, valid, discriminating, and responsive measure of quality of life in Chinese asthma patients. It is more sensitive than the generic SF-36 in detecting differences in asthma severity.
评估中国哮喘患者生活质量问卷（C-AQLQ）在中国哮喘患者样本中的可接受性、可靠性、有效性和反应性。
在基线和3个月后对患者进行C-AQLQ和简明健康调查问卷（SF-36）量表测评。评估哮喘严重程度和肺功能。收集必要数据以评估C-AQLQ的心理测量学特性，如可行性、内部一致性、重测信度、结构效度、区分效度、聚合效度和反应性。
137名患者完成了调查。总量表的Cronbach's alpha系数为0.96。因子分析产生了五个因子，总体上与五个提议的子量表相对应。除环境刺激外，轻度哮喘患者在所有子量表上的得分均高于中度/重度哮喘患者。肺功能测量和哮喘严重程度评分与C-AQOL的领域显著相关，但与SF-36的领域相关性较小。该问卷在随访期间检测到了患者哮喘状态的个体内变化。
结果初步支持C-AQLQ是一种可靠、有效、有区分力且能反映中国哮喘患者生活质量的测量工具。在检测哮喘严重程度差异方面，它比通用的SF-36更敏感。
