Yuxi Qin, Zhang Hanlai, Baili Yu, Shi Shihua
Altern Ther Health Med. 2017 Mar;23(2):36-42.
Context • Earthquakes are devastating disasters that have claimed countless lives in the past, partially owing to the danger of direct and indirect injuries to vital organs. In the deadly earthquake that occurred in Sichuan Province of China on May 12, 2008, some victims suffered from severe damage to multiple organs and tissue and developed sepsis, a systematic inflammatory reaction resulting from infection and trauma. Xuebijing injection (CCXG) could beneficial for improvement of clinical symptoms in those patients, but no research has yet examined its potential. Objective • The study intended to investigate whether a combination of conventional treatment and CCXG was superior to conventional treatment alone, or the control group (CG), in the treatment of clinical symptoms in patients with sepsis-induced acute kidney injury (AKI). Design • The study retrospectively analyzed the medical records of individuals who were injured in an earthquake that occurred in the Sichuan Province of China on May 12, 2008, and who developed AKI. Setting • The study took place in the hospital associated with Chengdu University of Traditional Chinese Medicine (Chengdu, Sichuan, China). Participants • Participants were 55 injured individuals who were treated at the hospital. The CG included 27 patients and the CCXG group included 28 patients. Intervention • Both the intervention group (CCXG group) and the CG received the conventional treatment. The CCXG group was also given intravenous drips containing 100 mL of CCXG. The CG was given 100 mL of a 10% normal saline injection in addition to conventional treatment. Both received the treatments within 30 to 40 min, 3 ×/d. Outcome Measures • Blood urea nitrogen (BUN), creatine phosphate kinase (CPK), serum creatinine (Cr), interleukin 1 (IL-1), and interleukin 6 (IL-6) were measured before treatment and on days 5, 7, and 10 after treatment. Results • The levels of CPK, BUN, Cr, and IL-6 for both groups were significantly lower than at baseline on day 5, 7, and 10 after treatment (P < .05). The levels of the CCXG group were significantly lower than those of the CG group on days 5, 7, and 10 (P < .05). Conclusions • As a supplement, CCXG is an effective method of improving the clinical symptoms of sepsis-induced AKI.
地震是极具破坏力的灾难，过去已夺走无数生命，部分原因是重要器官受到直接和间接损伤的危险。在2008年5月12日中国四川省发生的致命地震中，一些受害者多个器官和组织遭受严重损伤，并发展为脓毒症，这是一种由感染和创伤引起的全身性炎症反应。血必净注射液（CCXG）可能有助于改善这些患者的临床症状，但尚未有研究探讨其潜力。
本研究旨在调查在治疗脓毒症诱发的急性肾损伤（AKI）患者的临床症状时，常规治疗联合CCXG是否优于单纯常规治疗或对照组（CG）。
本研究回顾性分析了2008年5月12日在中国四川省发生的地震中受伤并发展为AKI的个体的病历。
本研究在成都中医药大学附属医院（中国四川成都）进行。
参与者为在该医院接受治疗的55名受伤个体。CG组包括27名患者，CCXG组包括28名患者。
干预组（CCXG组）和CG组均接受常规治疗。CCXG组还接受含100 mL CCXG的静脉滴注。CG组在常规治疗基础上还接受100 mL 10%生理盐水注射液。两组均在30至40分钟内接受治疗，每天3次。
在治疗前以及治疗后第5、7和10天测量血尿素氮（BUN）、磷酸肌酸激酶（CPK）、血清肌酐（Cr）、白细胞介素1（IL-1）和白细胞介素6（IL-6）。
两组的CPK、BUN、Cr和IL-6水平在治疗后第5、7和10天均显著低于基线水平（P < 0.05）。CCXG组在第5、7和10天的水平显著低于CG组（P < 0.
