Canas J Atilio, Lochrie Amanda, McGowan Amy Galena, Hossain Jobayer, Schettino Christopher, Balagopal P Babu
Pediatric Endocrinology, Metabolism and Diabetes, Nemours Children's Specialty Care, Jacksonville, Florida 32207.
Division of Psychology Nemours Children's Specialty Care, Wolfson Children's Hospital/Baptist Health, Jacksonville, Florida 32207.
J Clin Endocrinol Metab. 2017 Jun 1;102(6):1983-1990. doi: 10.1210/jc.2017-00185.
Carotenoids have been implicated in the regulation of adipocyte metabolism.
To compare the effects of mixed-carotenoid supplementation (MCS) versus placebo on adipokines and the accrual of abdominal adiposity in children with obesity.
Randomized (1:1), double-blind, placebo-controlled intervention trial to evaluate the effects of MCS over 6 months in a subspecialty clinic.
Twenty (6 male and 14 female) children with simple obesity [body mass index (BMI) > 90%], a mean age (± standard deviation) of 10.5 ± 0.4 years, and Tanner stage I to V were enrolled; 17 participants completed the trial.
MCS (which contains β-carotene, α-carotene, lutein, zeaxanthin, lycopene, astaxanthin, and γ-tocopherol) or placebo was administered daily.
Primary outcomes were change in β-carotene, abdominal fat accrual (according to magnetic resonance imaging), and BMI z-score; secondary outcomes were adipokines and markers of insulin resistance.
Cross-sectional analysis of β-carotene showed inverse correlation with BMI z-score, waist-to-height ratio, visceral adipose tissue, and subcutaneous adipose tissue (SAT) at baseline. MCS increased β-carotene, total adiponectin, and high-molecular-weight adiponectin compared with placebo. MCS led to a greater reduction in BMI z-score, waist-to-height ratio, and SAT compared with placebo. The percentage change in β-carotene directly correlated with the percentage change in SAT.
The decrease in BMI z-score, waist-to-height ratio, and SAT and the concomitant increase in the concentration of β-carotene and high-molecular-weight adiponectin by MCS suggest the putative beneficial role of MCS in children with obesity.
类胡萝卜素与脂肪细胞代谢的调节有关。
比较补充混合类胡萝卜素（MCS）与安慰剂对肥胖儿童脂肪因子及腹部肥胖累积的影响。
在一家专科诊所进行的随机（1:1）、双盲、安慰剂对照干预试验，以评估MCS在6个月内的效果。
招募了20名（6名男性和14名女性）单纯性肥胖儿童[体重指数（BMI）>90%]，平均年龄（±标准差）为10.5±0.4岁，坦纳分期为I至V期；17名参与者完成了试验。
每天给予MCS（含有β-胡萝卜素、α-胡萝卜素、叶黄素、玉米黄质、番茄红素、虾青素和γ-生育酚）或安慰剂。
主要结局为β-胡萝卜素的变化、腹部脂肪累积（根据磁共振成像）和BMI z评分；次要结局为脂肪因子和胰岛素抵抗标志物。
β-胡萝卜素的横断面分析显示，在基线时与BMI z评分、腰高比、内脏脂肪组织和皮下脂肪组织（SAT）呈负相关。与安慰剂相比，MCS增加了β-胡萝卜素、总脂联素和高分子量脂联素。与安慰剂相比，MCS导致BMI z评分、腰高比和SAT的降低幅度更大。β-胡萝卜素的百分比变化与SAT的百分比变化直接相关。
MCS使BMI z评分、腰高比和SAT降低，同时β-胡萝卜素和高分子量脂联素浓度升高，提示MCS对肥胖儿童可能具有有益作用。
