Kaur Amandeep, Kumar Vijay, Singh Simranjeet, Singh Joginder, Upadhyay Niraj, Datta Shivika, Singla Sourav, Kumar Virender
Department of Biotechnology, Lovely Professional University, Phagwara, 144411, Punjab, India.
Department of Chemistry, Lovely Professional University, Phagwara, 144411, Punjab, India.
3 Biotech. 2015 Oct;5(5):611-619. doi: 10.1007/s13205-015-0280-y. Epub 2015 Feb 15.
Keratitis is an inflammatory condition, characterized by involvement of corneal tissues. Most recurrent challenge of keratitis is infection. Bacteria, virus, fungus and parasitic organism have potential to cause infection. TLR are an important class of protein which has a major role in innate immune response to combat with pathogens. In last past years, extensive research efforts have provided considerable abundance information regarding the role of TLR in various types of keratitis. This paper focuses to review the recent literature illustrating amoebic, bacterial, fungal and viral keratitis associated with Toll-like receptor molecules and summarize existing thoughts on pathogenesis and treatment besides future probabilities for prevention against TLR-associated keratitis.
角膜炎是一种炎症性疾病，其特征是角膜组织受累。角膜炎最常见的反复挑战是感染。细菌、病毒、真菌和寄生虫都有可能引起感染。Toll样受体（TLR）是一类重要的蛋白质，在对抗病原体的固有免疫反应中起主要作用。在过去几年中，广泛的研究工作提供了大量关于TLR在各种类型角膜炎中作用的信息。本文着重回顾最近的文献，阐述与Toll样受体分子相关的阿米巴性、细菌性、真菌性和病毒性角膜炎，并总结关于发病机制和治疗的现有观点以及预防TLR相关角膜炎的未来可能性。
