Yan Zhenhua, Lu Guanghua, Sun Hongwei, Ma Binni
Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, China.
Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, China; College of Hydraulic and Civil Engineering, XiZang Agricultural and Animal Husbandry College, Linzhi 860000, China.
Chemosphere. 2017 Jul;178:165-172. doi: 10.1016/j.chemosphere.2017.03.043. Epub 2017 Mar 11.
Carbon nanotubes are increasingly entering the aquatic environment and may interact with other co-existing contaminants, such as antibiotics. However, whether these interactions may affect their bioavailability in aquatic organisms is the subject of considerable debate. The primary objective of this study was to assess the risks arising from the coexistence of roxithromycin (ROX) and multi-walled carbon nanotubes (MWCNTs) in waters containing natural organic matter (NOM), focusing on the distribution and bioaccumulation of ROX in crucian carp (Carassius auratus), and the related biochemical status. There were no significant differences in ROX bioaccumulation in fish following exposure to ROX with and without NOM. However, the further addition of MWCNTs significantly facilitated the bioaccumulation of ROX in the liver (32-80%), gill (15-74%), intestine (51-113%), and bile (15-67%) in different exposure periods. Meanwhile, a 0.3-fold increase in the metabolic enzyme activity and oxidative stress in the liver were markedly accelerated by the co-exposed MWCNTs compared to ROX alone. The findings imply that the ROX adsorbed on MWCNTs may be a higher threat to fish than ROX alone. The high and fast release of ROX from MWCNTs in bile salts and serum albumin may contribute to the enhancement in bioaccumulation and bioactivity of ROX in fish with MWCNTs.
碳纳米管正越来越多地进入水生环境，并可能与其他共存污染物相互作用，如抗生素。然而，这些相互作用是否会影响它们在水生生物中的生物利用度，是一个备受争议的话题。本研究的主要目的是评估在含有天然有机物（NOM）的水体中，罗红霉素（ROX）和多壁碳纳米管（MWCNTs）共存所产生的风险，重点关注ROX在鲫鱼（Carassius auratus）中的分布和生物累积情况，以及相关的生化状态。在有和没有NOM的情况下，暴露于ROX的鱼类中ROX的生物累积没有显著差异。然而，在不同暴露时期，进一步添加MWCNTs显著促进了ROX在肝脏（32 - 80%）、鳃（15 - 74%）、肠道（51 - 113%）和胆汁（15 - 67%）中的生物累积。同时，与单独的ROX相比，共同暴露的MWCNTs显著加速了肝脏中代谢酶活性的增加和氧化应激，增加了0.3倍。研究结果表明，吸附在MWCNTs上的ROX对鱼类的威胁可能比单独的ROX更大。MWCNTs在胆盐和血清白蛋白中ROX的高快速释放可能有助于增强ROX在与MWCNTs共存的鱼类中的生物累积和生物活性。
