Berendsen Agnes A M, Kang Jae H, van de Rest Ondine, Jankovic Nicole, Kampman Ellen, Kiefte-de Jong Jessica C, Franco Oscar H, Ikram M Arfan, Pikhart Hynek, Nilsson Lena Maria, Brenner Hermann, Boffetta Paolo, Rafnsson Snorri Bjorn, Gustafson Deborah, Kyrozis Andreas, Trichopoulou Antonia, Feskens Edith J M, Grodstein Francine, de Groot Lisette C P G M
Division of Human Nutrition, Wageningen University & Research, Wageningen, The Netherlands.
Dement Geriatr Cogn Disord. 2017;43(3-4):215-227. doi: 10.1159/000464269. Epub 2017 Mar 22.
To examine the association between a healthy diet, assessed by the Healthy Diet Indicator (HDI), and cognitive decline in older adults.
Data from 21,837 participants aged ≥55 years from 3 cohorts (Survey in Europe on Nutrition and the Elderly, a Concerted Action [SENECA], Rotterdam Study [RS], Nurses' Health Study [NHS]) were analyzed. HDI scores were based on intakes of saturated fatty acids, polyunsaturated fatty acids, mono- and disaccharides, protein, cholesterol, fruits and vegetables, and fiber. The Telephone Interview for Cognitive Status in NHS and Mini-Mental State Examination in RS and SENECA were used to assess cognitive function from multiple repeated measures. Using multivariable-adjusted, mixed linear regression, mean differences in annual rates of cognitive decline by HDI quintiles were estimated.
Multivariable-adjusted differences in rates in the highest versus the lowest HDI quintile were 0.01 (95% CI -0.01, 0.02) in NHS, 0.00 (95% CI -0.02, 0.01) in RS, and 0.00 (95% CI -0.05, 0.05) in SENECA with a pooled estimate of 0.00 (95% CI -0.01, 0.01), I2 = 0%.
A higher HDI score was not related to reduced rates of cognitive decline in European and American older adults.
通过健康饮食指标（HDI）评估健康饮食与老年人认知能力下降之间的关联。
分析了来自3个队列（欧洲营养与老年人调查协同行动[SENECA]、鹿特丹研究[RS]、护士健康研究[NHS]）的21837名年龄≥55岁参与者的数据。HDI得分基于饱和脂肪酸、多不饱和脂肪酸、单糖和双糖、蛋白质、胆固醇、水果和蔬菜以及纤维的摄入量。NHS中的认知状态电话访谈以及RS和SENECA中的简易精神状态检查用于通过多次重复测量来评估认知功能。使用多变量调整的混合线性回归，估计了按HDI五分位数划分的认知下降年率的平均差异。
在NHS中，HDI最高五分位数与最低五分位数的多变量调整率差异为0.01（95%CI -0.01，0.02），在RS中为0.00（95%CI -0.02，0.01），在SENECA中为0.00（95%CI -0.05，有一个汇总估计值为0.00（95%CI -0.01，0.01），I2 = 0%。
较高的HDI得分与欧美老年人认知能力下降率降低无关。 0.05），
