Jiang Jingjing, Xia Jili, Zang Yang, Diao Guowang
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Sensors (Basel). 2021 Nov 21;21(22):7742. doi: 10.3390/s21227742.
Recently, electrochemistry- and photoelectrochemistry-based biosensors have been regarded as powerful tools for trace monitoring of carcinoembryonic antigen (CEA) due to the fact of their intrinsic advantages (e.g., high sensitivity, excellent selectivity, small background, and low cost), which play an important role in early cancer screening and diagnosis and benefit people's increasing demands for medical and health services. Thus, this mini-review will introduce the current trends in electrochemical and photoelectrochemical biosensors for CEA assay and classify them into two main categories according to the interactions between target and biorecognition elements: immunosensors and aptasensors. Some recent illustrative examples are summarized for interested readers, accompanied by simple descriptions of the related signaling strategies, advanced materials, and detection modes. Finally, the development prospects and challenges of future electrochemical and photoelectrochemical biosensors are considered.
近年来，基于电化学和光电化学的生物传感器因其固有优势（如高灵敏度、优异的选择性、低背景和低成本），被视为癌胚抗原（CEA）痕量监测的有力工具，这在早期癌症筛查和诊断中发挥着重要作用，满足了人们对医疗卫生服务日益增长的需求。因此，本综述将介绍用于CEA检测的电化学和光电化学生物传感器的当前趋势，并根据目标与生物识别元件之间的相互作用将其分为两大类：免疫传感器和适配体传感器。为感兴趣的读者总结了一些近期的典型示例，并对相关信号策略、先进材料和检测模式进行了简要描述。最后，探讨了未来电化学和光电化学生物传感器的发展前景与挑战。
