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聚酮化合物的立体控制：化学生物学研究

Polyketide stereocontrol: a study in chemical biology.

作者信息

Weissman Kira J

机构信息

UMR 7365, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), CNRS-Université de Lorraine, Biopôle de l'Université de Lorraine, Campus Biologie Santé, Avenue de la Forêt de Haye, BP 50184, 54505 Vandœuvre-lès-Nancy Cedex, France.

出版信息

Beilstein J Org Chem. 2017 Feb 24;13:348-371. doi: 10.3762/bjoc.13.39. eCollection 2017.

DOI:10.3762/bjoc.13.39
PMID:28326145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5331325/
Abstract

The biosynthesis of reduced polyketides in bacteria by modular polyketide synthases (PKSs) proceeds with exquisite stereocontrol. As the stereochemistry is intimately linked to the strong bioactivity of these molecules, the origins of stereochemical control are of significant interest in attempts to create derivatives of these compounds by genetic engineering. In this review, we discuss the current state of knowledge regarding this key aspect of the biosynthetic pathways. Given that much of this information has been obtained using chemical biology tools, work in this area serves as a showcase for the power of this approach to provide answers to fundamental biological questions.

摘要

在细菌中，模块化聚酮合酶（PKSs）合成还原型聚酮化合物的过程具有精确的立体化学控制。由于立体化学与这些分子的强大生物活性密切相关，在试图通过基因工程创造这些化合物的衍生物时，立体化学控制的起源备受关注。在这篇综述中，我们讨论了关于生物合成途径这一关键方面的当前知识状态。鉴于这些信息大多是通过化学生物学工具获得的，该领域的工作展示了这种方法在解答基本生物学问题方面的强大力量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dddf/5331325/601126cc01a1/Beilstein_J_Org_Chem-13-348-g019.jpg
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