Lee Jung Hae, Suh Heuy Sun
Department of Family Medicine, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, Korea.
J Bone Metab. 2017 Feb;24(1):51-58. doi: 10.11005/jbm.2017.24.1.51. Epub 2017 Feb 28.
There are growing concerns about the role of vitamin D deficiency in cardiovascular diseases. Therefore, we investigated the correlation between serum 25-hydroxy-vitamin D (25[OH]D) and arterial stiffness among Korean adults.
We retrospectively reviewed the medical charts of 302 people (115 women and 187 men) who visited a tertiary hospital from January 2015 to December 2016. Serum 25(OH)D was measured using the radioimmunoassay technique, and brachial-ankle pulse wave velocity (baPWV) was measured using an automatic wave analyzer. We obtained the doctor's report on the medical history of the participants, their alcohol consumption and smoking habits, and their exercise status. Metabolic syndrome was diagnosed based on guidelines from the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP III) and the International Diabetes Federation (IDF). Results of basic blood tests and physical assessment were also collected.
In the Pearson correlation analysis, serum 25(OH)D and baPWV showed a statistically significant inverse relationship (r=-0.279, <0.001). Using multiple regression analysis, and after adjusting for possible confounders, serum 25(OH)D concentration was found to be significantly associated with baPWV (β=-0.121, =0.011).
We observed an association between serum 25(OH)D concentration and arterial stiffness. Further studies involving larger sample sizes will be needed to confirm this associations.
维生素D缺乏在心血管疾病中的作用日益受到关注。因此，我们调查了韩国成年人血清25-羟基维生素D（25[OH]D）与动脉僵硬度之间的相关性。
我们回顾性分析了2015年1月至2016年12月期间在一家三级医院就诊的302人（115名女性和187名男性）的病历。采用放射免疫分析技术测定血清25(OH)D，使用自动波分析仪测量肱踝脉搏波速度（baPWV）。我们获取了参与者的病史、饮酒和吸烟习惯以及运动状况的医生报告。根据美国国家胆固醇教育计划（NCEP）成人治疗小组（ATP III）和国际糖尿病联盟（IDF）的指南诊断代谢综合征。还收集了基本血液检查和身体评估的结果。
在Pearson相关性分析中，血清25(OH)D与baPWV呈显著负相关（r = -0.279，<0.001）。使用多元回归分析并调整可能的混杂因素后，发现血清25(OH)D浓度与baPWV显著相关（β = -0.121，=0.011）。
我们观察到血清25(OH)D浓度与动脉僵硬度之间存在关联。需要进一步进行更大样本量的研究来证实这种关联。
