Merel Susan E, Paauw Douglas S
Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, Washington.
J Am Geriatr Soc. 2017 Jul;65(7):1578-1585. doi: 10.1111/jgs.14870. Epub 2017 Mar 21.
Prescribing medications, recognizing and managing medication side effects and drug interactions, and avoiding polypharmacy are all essential skills in the care of older adults in primary care. Important side effects of medications commonly prescribed in older adults (statins, proton pump inhibitors, trimethoprim-sulfamethoxazole and fluoroquinolone antibiotics, zolpidem, nonsteroidal antiinflammatory drugs, selective serotonin reuptake inhibitors, dipeptidyl peptidase 4 inhibitors) were reviewed. Important drug interactions with four agents or classes (statins, warfarin, factor Xa inhibitors, and calcium channel blockers) are discussed.
在初级保健中照顾老年人时，开具药物处方、识别和处理药物副作用及药物相互作用，以及避免多重用药都是必不可少的技能。本文回顾了老年人常用药物（他汀类药物、质子泵抑制剂、甲氧苄啶-磺胺甲恶唑和氟喹诺酮类抗生素、唑吡坦、非甾体抗炎药、选择性5-羟色胺再摄取抑制剂、二肽基肽酶4抑制剂）的重要副作用。并讨论了与四种药物或药物类别（他汀类药物、华法林、Xa因子抑制剂和钙通道阻滞剂）相关的重要药物相互作用。
