牙科护理中老年患者的药物相互作用：一项横断面研究。

Drug-Drug Interactions in Elderly Adults in Dentistry Care: a Cross-Sectional Study.

作者信息

Abbaszadeh Elham, Ganjalikhan Hakemi Niloofar, Rad Maryam, Torabi Molook

机构信息

Dept. of Oral Medicine, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.

Dentist, Private Practice, Kerman, Iran.

出版信息

J Dent (Shiraz). 2022 Dec;23(4):459-466. doi: 10.30476/DENTJODS.2021.91067.1549.

DOI:10.30476/DENTJODS.2021.91067.1549

PMID:36718158

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9883622/

Abstract

STATEMENT OF THE PROBLEM

Given the increase in the population of the elderly patients and the risk of systemic diseases in these individuals, the prevalence of the intake of various drugs is higher in elderly patients, which exposes them to the side effects of drugs including potential drug-drug interactions (DDIs).

PURPOSE

Therefore, the present study is an attempt to evaluate the drug interactions between the drugs used by the elderly patients visiting Kerman School of Dentistry and the common dental drugs in 2020.

MATERIALS AND METHOD

This cross-sectional study was conducted on the elderly patients (≥60 years (who referred to Kerman School of Dentistry for dental problems. After obtaining the oral informed consent and collecting demographic information, the drugs used by the patients and their systemic diseases were questioned, listed, and compared with the drugs mentioned in their files. The drug interactions with the common dental drugs were studied in the elderly patients using the www.drugs.com website. Chi-square, T, ANOVA, Kruskal-Wallis, and Mann-Whitney tests were used to compare the variables. The significance level was 0.05.

RESULTS

Of participants included in this study, 78 (52%) were female and 72(48%) were male. The average age of these patients was 71.27 6.32 years. The most common systemic diseases were hypertension (57.3%), heart diseases (42.0%), and diabetes mellitus (40.7%). Our analysis of the DDIs between 11 commonly prescribed dental drugs and 95 drugs used by the patients revealed 212 DDIs (21.7% minor, 68.3% moderate, and 9.9% major interactions). There was a significant relationship between the number of drugs and DDIs, whereas DDIs had no significant relationship with gender and educational level.

CONCLUSION

The results reflected the high percentage of DDIs among the patients. In addition, there was a significant relationship between polypharmacy, which is highly prevalent among the elderly patients, and drug interactions.

摘要

问题陈述

鉴于老年患者人口增加以及这些个体存在全身性疾病的风险，老年患者中各种药物的摄入量普遍较高，这使他们面临药物副作用，包括潜在的药物相互作用（DDIs）。

目的

因此，本研究旨在评估2020年访问克尔曼牙科学院的老年患者所使用药物与常见牙科药物之间的药物相互作用。

材料与方法

本横断面研究针对老年患者（≥60岁）进行，这些患者因牙科问题前往克尔曼牙科学院就诊。在获得口头知情同意并收集人口统计学信息后，询问、列出患者使用的药物及其全身性疾病，并与他们病历中提及的药物进行比较。使用www.drugs.com网站研究老年患者中与常见牙科药物的药物相互作用。采用卡方检验、T检验、方差分析、克鲁斯卡尔 - 沃利斯检验和曼 - 惠特尼检验来比较变量。显著性水平为0.05。

结果

本研究纳入的参与者中，78名（52%）为女性，72名（48%）为男性。这些患者的平均年龄为71.27 ± 6.32岁。最常见的全身性疾病是高血压（57.3%）、心脏病（42.0%）和糖尿病（40.7%）。我们对11种常用牙科药物与患者使用的95种药物之间的药物相互作用分析显示有212种药物相互作用（21.7%为轻度，68.3%为中度，9.9%为重度相互作用）。药物数量与药物相互作用之间存在显著关系，而药物相互作用与性别和教育水平无显著关系。