Benoit B, Martin-Misener R, Newman A, Latimer M, Campbell-Yeo M
School of Nursing, Dalhousie University, Halifax, Nova Scotia, Canada.
Centre for Pediatric Pain Research, IWK Health Centre, Halifax, NS, Canada.
Acta Paediatr. 2017 Jul;106(7):1053-1066. doi: 10.1111/apa.13839. Epub 2017 May 9.
A systematic scoping search to describe the neurophysiological methods used in infant acute pain assessment research was conducted. Of the 2411 abstracts screened, 19 articles were retained. Nine studies utilised near-infrared spectroscopy (NIRS), two utilised functional magnetic resonance imaging (fMRI), and eight utilised electroencephalography (EEG). There was methodological variability in studies utilising NIRS, whereas EEG and fMRI studies reported consistent methods. Of the eight EEG studies, six identified a nociceptive-specific event-related potential.
While more methodologically rigorous studies are needed, ERPs appear to hold some promise as indicators of infant nociception during clinical procedures to supplement existing measures.
进行了一项系统性的范围搜索，以描述婴儿急性疼痛评估研究中使用的神经生理学方法。在筛选的2411篇摘要中，保留了19篇文章。9项研究使用了近红外光谱法（NIRS），2项使用了功能磁共振成像（fMRI），8项使用了脑电图（EEG）。使用NIRS的研究存在方法学上的差异，而EEG和fMRI研究报告的方法较为一致。在8项EEG研究中，6项确定了一种伤害性特异性事件相关电位。
虽然需要更多方法学上严谨的研究，但事件相关电位作为临床操作中婴儿伤害感受的指标似乎有一定前景，可补充现有测量方法。
