NDRG3在乳腺癌患者中的临床意义。
Clinical significance of NDRG3 in patients with breast cancer.
作者信息
Estiar Mehrdad Asghari, Zare Ali-Akbar, Esmaeili Rezvan, Farahmand Leila, Fazilaty Hassan, Jafari Davood, Samadi Tannaz, Majidzadeh-A Keivan
机构信息
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Recombinant Proteins Department, Breast Cancer Research Center, ACECR, Tehran, Iran.
出版信息
Future Oncol. 2017 May;13(11):961-969. doi: 10.2217/fon-2016-0457. Epub 2017 Feb 27.
AIM
The expression level of NDRG3 gene is investigated among breast cancer (BC) patients.
METHODS
Real-time quantitative PCR was performed.
RESULTS
NDRG3 was downregulated in BC patients particularly in advanced stage of the disease. HER2 status was significantly correlated with the expression of NDRG3. Also, triple-negative BC patients showed low levels of NDRG3 expression in comparison to other subtypes. Lastly, the expression of NDRG3 had significant impact on survival, with NDRG3 downregulated patients having the worst event-free survival rate among others.
CONCLUSION
We have presented that NDRG3 might be a tumor suppressor candidate. NDRG3 downregulation might be involved in the tumorigenesis and development of invasive BC in an advanced phase of the disease.
目的
研究乳腺癌（BC）患者中NDRG3基因的表达水平。
方法
进行实时定量PCR。
结果
NDRG3在BC患者中表达下调，尤其是在疾病晚期。HER2状态与NDRG3的表达显著相关。此外，与其他亚型相比，三阴性BC患者的NDRG3表达水平较低。最后，NDRG3的表达对生存有显著影响，NDRG3表达下调的患者无事件生存率最差。
结论
我们提出NDRG3可能是一种肿瘤抑制候选基因。NDRG3下调可能参与了侵袭性BC在疾病晚期的肿瘤发生和发展。
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