NDRG3 高表达与胃癌患者预后不良相关。
High expression of NDRG3 correlates with poor prognosis in gastric cancer patients.
机构信息
Digestuve Diseases, The Affiliated People's Hospital. Jiangsu University.
Zhenjiang Mental Health Center.
出版信息
Rev Esp Enferm Dig. 2021 Jul;113(7):524-528. doi: 10.17235/reed.2021.7723/2020.
INTRODUCTION
N-myc downstream-regulated gene 3 (NDRG3) is an important member of the NDRG family and is linked with malignant tumors. However, the relationship between NDRG3 and gastric cancer (GC) is vague.
MATERIAL AND METHODS
Western blot, qRT-PCR and immunohistochemistry (IHC) detected the expression of NDRG3 in GC cell lines and GC tissues; public databases were used to analyze NDRG3 in GC patients and the association with EBV infection.
RESULTS
NDRG3 was up-regulated in GC cell lines and tissues. IHC data suggested that NDRG3 was correlated with histologic grade (p = 0.006) and is associated with patient survival.
DISCUSSION
thus, NDRG3 may be a novel predictor of GC prognosis.
简介
N- myc 下游调节基因 3（NDRG3）是 NDRG 家族的重要成员，与恶性肿瘤有关。然而，NDRG3 与胃癌（GC）的关系尚不清楚。
材料与方法
Western blot、qRT-PCR 和免疫组织化学（IHC）检测 NDRG3 在 GC 细胞系和 GC 组织中的表达；公共数据库用于分析 GC 患者的 NDRG3 与 EBV 感染的关联。
结果
NDRG3 在 GC 细胞系和组织中上调。IHC 数据表明，NDRG3 与组织学分级相关（p = 0.006），并与患者生存相关。
讨论
因此，NDRG3 可能是 GC 预后的一个新的预测因子。
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