Digestuve Diseases, The Affiliated People's Hospital. Jiangsu University.
Zhenjiang Mental Health Center.
Rev Esp Enferm Dig. 2021 Jul;113(7):524-528. doi: 10.17235/reed.2021.7723/2020.
N-myc downstream-regulated gene 3 (NDRG3) is an important member of the NDRG family and is linked with malignant tumors. However, the relationship between NDRG3 and gastric cancer (GC) is vague.
Western blot, qRT-PCR and immunohistochemistry (IHC) detected the expression of NDRG3 in GC cell lines and GC tissues; public databases were used to analyze NDRG3 in GC patients and the association with EBV infection.
NDRG3 was up-regulated in GC cell lines and tissues. IHC data suggested that NDRG3 was correlated with histologic grade (p = 0.006) and is associated with patient survival.
thus, NDRG3 may be a novel predictor of GC prognosis.
N- myc 下游调节基因 3（NDRG3）是 NDRG 家族的重要成员，与恶性肿瘤有关。然而，NDRG3 与胃癌（GC）的关系尚不清楚。
Western blot、qRT-PCR 和免疫组织化学（IHC）检测 NDRG3 在 GC 细胞系和 GC 组织中的表达；公共数据库用于分析 GC 患者的 NDRG3 与 EBV 感染的关联。
NDRG3 在 GC 细胞系和组织中上调。IHC 数据表明，NDRG3 与组织学分级相关（p = 0.006），并与患者生存相关。
因此，NDRG3 可能是 GC 预后的一个新的预测因子。
