DiPersio L, Kyriazis A P, Michael J G, Pesce A J
J Natl Cancer Inst. 1979 Feb;62(2):375-9.
With the use of circulating human lactate dehydrogenase (LDH) as a tumor marker, growth and remission of human tumor lines SW480, HEp-2, and Clouser, implanted into female BALB/c athymic nude mice, were followed during therapy. Three types of therapy were used: X-radiation, cyclophosphamide, and diphtheria toxin. After therapy tumor sizes were measured with calipers and compared to changes in the levels of circulating human LDH. Changes in LDH levels paralleled changes in tumor size, but the enzyme fluctuations were more pronounced. Mice bearing intraperitoneally growing SW480 and HEp-2 tumors were effectively treated with diphtheria toxin, and the measurement of circulating LDH was examined as a parameter for gauging the effectiveness of chemotherapy on tumors that could not be visualized. Circulating human LDH can be used to detect intraperitoneal tumor growth and/or remission and to predict death of the animal due to the tumor.
将人源SW480、HEp-2和Clouser肿瘤细胞系接种到雌性BALB/c无胸腺裸鼠体内，利用循环人乳酸脱氢酶（LDH）作为肿瘤标志物，在治疗过程中对肿瘤的生长和缓解情况进行跟踪。采用了三种治疗方法：X射线照射、环磷酰胺和白喉毒素。治疗后用卡尺测量肿瘤大小，并与循环人LDH水平的变化进行比较。LDH水平的变化与肿瘤大小的变化平行，但酶的波动更为明显。腹腔内生长SW480和HEp-2肿瘤的小鼠用白喉毒素治疗有效，检测循环LDH作为衡量化疗对不可见肿瘤有效性的参数。循环人LDH可用于检测腹腔内肿瘤的生长和/或缓解，并预测动物因肿瘤死亡。
