Liu Yansong, Yu Xinnian, Yang Bixiu, Zhang Fuquan, Zou Wenhua, Na Aiguo, Zhao Xudong, Yin Guangzhong
Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200092, China.
Wuxi Institute of Technology, Wuxi, 214121, Jiangsu Province, China.
BMC Psychiatry. 2017 Mar 21;17(1):103. doi: 10.1186/s12888-017-1264-8.
Overgeneral autobiographical memory has been identified as a risk factor for the onset and maintenance of depression. However, little is known about the underlying mechanisms that might explain overgeneral autobiographical memory phenomenon in depression. The purpose of this study was to test the mediation effects of rumination on the relationship between overgeneral autobiographical memory and depressive symptoms. Specifically, the mediation effects of brooding and reflection subtypes of rumination were examined in patients with major depressive disorder.
Eighty-seven patients with major depressive disorder completed the 17-item Hamilton Depression Rating Scale, Ruminative Response Scale, and Autobiographical Memory Test. Bootstrap mediation analysis for simple and multiple mediation models through the PROCESS macro was applied.
Simple mediation analysis showed that rumination significantly mediated the relationship between overgeneral autobiographical memory and depression symptoms. Multiple mediation analyses showed that brooding, but not reflection, significantly mediated the relationship between overgeneral autobiographical memory and depression symptoms.
Our results indicate that global rumination partly mediates the relationship between overgeneral autobiographical memory and depressive symptoms in patients with major depressive disorder. Furthermore, the present results suggest that the mediating role of rumination in the relationship between overgeneral autobiographical memory and depression is mainly due to the maladaptive brooding subtype of rumination.
过度概括的自传体记忆已被确定为抑郁症发作和维持的一个风险因素。然而，对于可能解释抑郁症中过度概括的自传体记忆现象的潜在机制知之甚少。本研究的目的是检验沉思对过度概括的自传体记忆与抑郁症状之间关系的中介作用。具体而言，在重度抑郁症患者中考察了沉思的沉思和反思亚型的中介作用。
87名重度抑郁症患者完成了17项汉密尔顿抑郁量表、沉思反应量表和自传体记忆测试。应用通过PROCESS宏对简单和多重中介模型进行的自抽样中介分析。
简单中介分析表明，沉思显著中介了过度概括的自传体记忆与抑郁症状之间的关系。多重中介分析表明，沉思而非反思显著中介了过度概括的自传体记忆与抑郁症状之间的关系。
我们的结果表明，总体沉思部分中介了重度抑郁症患者过度概括的自传体记忆与抑郁症状之间的关系。此外，目前的结果表明，沉思在过度概括的自传体记忆与抑郁之间关系中的中介作用主要归因于沉思的适应不良性沉思亚型。
