Parikh Rohan B, Grant Matthew
Texas Heart Institute, 6770 Bertner Avenue, Houston, Tx, 77030, USA.
Yale School of Medicine, 333 Cedar St, New Haven, CT, 06510, USA.
Ann Clin Microbiol Antimicrob. 2017 Mar 21;16(1):14. doi: 10.1186/s12941-017-0190-4.
Mycobacterium goodii is an infrequent human pathogen which has been implicated in prosthesis related infections and penetrating injuries. It is often initially misidentified as a gram-positive rod by clinical microbiologic laboratories and should be considered in the differential diagnosis.
We describe here the second reported case of M. goodii endocarditis. Species level identification was performed by 16S rDNA (ribosomal deoxyribonucleic acid) gene sequencing. The patient was successfully treated with mitral valve replacement and a prolonged combination of ciprofloxacin and trimethoprim/sulfamethoxazole.
Confirmation of the diagnosis utilizing molecular techniques and drug susceptibility testing allowed for successful treatment of this prosthetic infection.
古氏分枝杆菌是一种罕见的人类病原体，与假体相关感染和穿透性损伤有关。临床微生物实验室通常最初会将其误鉴定为革兰氏阳性杆菌，在鉴别诊断时应予以考虑。
我们在此描述第二例已报道的古氏分枝杆菌心内膜炎病例。通过16S rDNA（核糖体脱氧核糖核酸）基因测序进行菌种水平鉴定。该患者通过二尖瓣置换术以及环丙沙星和甲氧苄啶/磺胺甲恶唑的长期联合治疗成功治愈。
利用分子技术和药敏试验确诊使得该假体感染得以成功治疗。
