Guégan Jean-François
Biol Aujourdhui. 2016;210(4):205-209. doi: 10.1051/jbio/2016023. Epub 2017 Mar 22.
In the light of a double approach, at first empirical, later theoretical and comparative, illustrated by the example of the Buruli ulcer and its mycobacterial agent Mycobacterium ulcerans on which I focused my research activity these last ten years by studying determinants and factors of emerging infectious or parasitic diseases, the complexity of events explaining emerging diseases will be presented. The cascade of events occurring at various levels of spatiotemporal scales and organization of life, which lead to the numerous observed emergences, nowadays requires better taking into account the interactions between host(s), pathogen(s) and the environment by including the behavior of both individuals and the population. In numerous research studies on emerging infectious diseases, microbial hazard is described rather than infectious disease risk, the latter resulting from the confrontation between an association of threatening phenomena, or hazards, and a susceptible population. Beyond, the theme of emerging infectious diseases and its links with global environmental and societal changes leads to reconsider some well-established knowledge in infectiology and parasitology.
鉴于采用了双重方法，起初是经验性的，后来是理论性和比较性的，以布鲁里溃疡及其分枝杆菌病原体溃疡分枝杆菌为例进行说明。在过去十年中，我通过研究新发传染病或寄生虫病的决定因素和因素，将研究活动聚焦于此。本文将阐述解释新发疾病的事件的复杂性。在时空尺度和生命组织的各个层面上发生的一系列事件导致了众多观察到的疾病出现，如今需要通过纳入个体和群体的行为，更好地考虑宿主、病原体与环境之间的相互作用。在众多关于新发传染病的研究中，描述的是微生物危害而非传染病风险，后者是由一系列威胁性现象或危害与易感人群之间的对抗所导致的。此外，新发传染病主题及其与全球环境和社会变化的联系促使我们重新审视传染病学和寄生虫学中的一些既定知识。
