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Akirin2 通过 ERK1/2 和 NFATc1 信号通路调节猪骨骼肌卫星细胞的增殖和分化。

Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways.

机构信息

Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, P. R. China.

出版信息

Sci Rep. 2017 Mar 22;7:45156. doi: 10.1038/srep45156.

DOI:10.1038/srep45156
PMID:28327665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5361102/
Abstract

Akirin2, a novel nuclear factor, plays an important role in myogenesis. To investigate the role of Akirin2 in proliferation and differentiation of porcine skeletal muscle satellite cells, Akirin2 overexpression and Akirin2 silence technologies were employed. Our results showed that overexpression of Akirin2 markedly enhanced the proliferation and differentiation of porcine skeletal muscle satellite cells, whereas silencing of Akirin2 got the opposite results. Furthermore, our results showed that Akirin2 affected proliferation and differentiation of porcine skeletal muscle satellite cells through extracellular-signal regulated kinase-1/2 (ERK1/2) and NFATc1 signaling pathways. These results indicate that Akirin2 can effectively promote skeletal muscle satellite cells proliferation and differentiation, acting through ERK1/2- and NFATc1-dependent mechanisms.

摘要

Akirin2，一种新型核因子，在肌肉发生中发挥重要作用。为了研究 Akirin2 在猪骨骼肌卫星细胞增殖和分化中的作用，采用了 Akirin2 过表达和 Akirin2 沉默技术。我们的结果表明，Akirin2 的过表达显著增强了猪骨骼肌卫星细胞的增殖和分化，而 Akirin2 的沉默则得到了相反的结果。此外，我们的结果表明，Akirin2 通过细胞外信号调节激酶 1/2（ERK1/2）和 NFATc1 信号通路影响猪骨骼肌卫星细胞的增殖和分化。这些结果表明，Akirin2 可以通过 ERK1/2-和 NFATc1 依赖性机制有效促进骨骼肌卫星细胞的增殖和分化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/8ac2a24c6b0b/srep45156-f12.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/9f00a2d3c891/srep45156-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/562af867ed3a/srep45156-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/629a570fef38/srep45156-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/04c1f72e2197/srep45156-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/994b11e3a15f/srep45156-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/110ef532c47a/srep45156-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/3605a3638415/srep45156-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/dbf566f2674a/srep45156-f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/8ac2a24c6b0b/srep45156-f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/e4776246148e/srep45156-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/f4b7588fea45/srep45156-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/7851164cc53f/srep45156-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/9f00a2d3c891/srep45156-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/562af867ed3a/srep45156-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/629a570fef38/srep45156-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/04c1f72e2197/srep45156-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/994b11e3a15f/srep45156-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/110ef532c47a/srep45156-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/3605a3638415/srep45156-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/dbf566f2674a/srep45156-f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c1/5361102/8ac2a24c6b0b/srep45156-f12.jpg

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