Ueno K, Tanaka Y, Ando S
Department of Biochemistry, Tokyo Metropolitan Institute of Gerontology, Japan.
Neurosci Lett. 1988 Feb 3;84(3):297-301. doi: 10.1016/0304-3940(88)90524-1.
Release of free fatty acids from rat cerebral synaptosomes, synaptic plasma membranes and mitochondria was studied under in vitro hypoxia. The release increased in the absence of oxygen. Removal of calcium ions from the medium suppressed the release. These trends were similar in every subcellular fraction tested. The data imply that the release of free fatty acids is caused by lack of oxygen but not lack of glucose, and that the presence of extracellular calcium is injurious to cells. An energy-independent mechanism for the release of free fatty acids is suggested.
在体外缺氧条件下，研究了大鼠脑突触体、突触质膜和线粒体中游离脂肪酸的释放情况。在无氧条件下，释放量增加。从培养基中去除钙离子可抑制释放。在每个测试的亚细胞组分中，这些趋势都是相似的。数据表明，游离脂肪酸的释放是由缺氧而非葡萄糖缺乏引起的，并且细胞外钙的存在对细胞有害。提出了一种与能量无关的游离脂肪酸释放机制。
