Bunnell B N, Meyerhoff J L, Kant G J
Department of Medical Neurosciences, Walter Reed Army Medical Center, Washington, DC 20307.
Pharmacol Biochem Behav. 1988 Jan;29(1):151-5. doi: 10.1016/0091-3057(88)90288-2.
Exposure to physical stressors has been shown to produce increases in pituitary cyclic AMP in laboratory rats. In this experiment, the generality of these findings has been extended to include a psychological stressor, defined as returning the animals to a situation in which they had been exposed to footshock for four days. Rats in the psychological stress group exhibited increases in pituitary cyclic AMP and in plasma corticosterone and prolactin which were similar to those seen in animals that received the physical stressor on the test day. At present it is not known whether the effects are due to associative conditioning or to sensitization of the neuroendocrine system following repeated presentations of the physical stressor.
在实验大鼠中，暴露于物理应激源已被证明会导致垂体环磷酸腺苷（cAMP）增加。在本实验中，这些发现的普遍性已扩展到包括一种心理应激源，即让动物回到它们曾遭受四天电击的环境中。心理应激组的大鼠垂体环磷酸腺苷、血浆皮质酮和催乳素均增加，这些变化与在测试当天接受物理应激源的动物所观察到的相似。目前尚不清楚这些影响是由于联想性条件作用还是由于反复暴露于物理应激源后神经内分泌系统的敏感化所致。
