Kant G J, Bunnell B N, Mougey E H, Pennington L L, Meyerhoff J L
Pharmacol Biochem Behav. 1983 Jun;18(6):967-71. doi: 10.1016/s0091-3057(83)80022-7.
The effects of five putative stressors (saline injection, cold exposure, forced running, immobilization, and footshock) on levels of pituitary cyclic AMP, plasma prolactin, corticosterone and growth hormone were examined. In naive rats exposed to 15 min of these stressors for the first time, running, immobilization and footshock increased levels of pituitary cyclic AMP, plasma corticosterone and prolactin and decreased growth hormone, typical of stress response in the rat. Cold exposure only increased corticosterone and saline injection did not affect any measured parameter. In rats chronically exposed to the same stressor (once a day for 15 min) for 10 days immediately prior to the experiment, an attenuated pituitary cyclic AMP and plasma prolactin response was seen upon application of 15 min of that stressor on the day of the experiment, compared to the responses observed in the naive rats.
研究了五种假定应激源（注射生理盐水、冷暴露、强迫跑步、固定和电击足部）对垂体环磷酸腺苷（cAMP）水平、血浆催乳素、皮质酮和生长激素水平的影响。首次暴露于这些应激源15分钟的未处理大鼠中，跑步、固定和电击足部会增加垂体cAMP水平、血浆皮质酮和催乳素水平，并降低生长激素水平，这是大鼠应激反应的典型表现。冷暴露仅增加皮质酮，而注射生理盐水不影响任何测量参数。在实验前10天每天一次、每次15分钟长期暴露于相同应激源的大鼠中，与未处理大鼠相比，在实验当天施加该应激源15分钟后，垂体cAMP和血浆催乳素反应减弱。
