大脑和垂体对压力的环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）反应：压力会升高垂体中的环磷酸腺苷。

Cyclic AMP and cyclic GMP response to stress in brain and pituitary: stress elevates pituitary cyclic AMP.

作者信息

Kant G J, Meyerhoff J L, Bunnell B N, Lenox R H

出版信息

Pharmacol Biochem Behav. 1982 Nov;17(5):1067-72. doi: 10.1016/0091-3057(82)90495-6.

Abstract

Male rats were exposed to six stressors (saline injection, cold, forced running, Formalin injection, immobilization, electric footshock) for 15, 30, or 60 min. Following sacrifice by microwave irradiation, cyclic AMP and cyclic GMP levels were measured in pituitary, pineal and 8 regions of rat brain. All stressors except saline increased plasma corticosterone, plasma prolactin and pituitary cyclic AMP levels compared to control animals. The magnitude of the pituitary cyclic AMP response was highly correlated with the intensity of the stress as determined by the levels of plasma prolactin. Electric footshock increased pituitary cyclic AMP levels over 10 fold and plasma prolactin over 60 fold. Cyclic AMP levels in other brain regions were not altered. Cerebellar cyclic GMP was increased only by stressors that involved increased motor activity.

摘要

将雄性大鼠暴露于六种应激源（注射生理盐水、寒冷、强迫跑步、注射福尔马林、固定、电击足部）下15、30或60分钟。通过微波辐射处死后，测量垂体、松果体和大鼠脑的8个区域中的环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）水平。与对照动物相比，除生理盐水外的所有应激源均增加了血浆皮质酮、血浆催乳素和垂体cAMP水平。垂体cAMP反应的幅度与由血浆催乳素水平所确定的应激强度高度相关。电击足部使垂体cAMP水平增加超过10倍，血浆催乳素增加超过60倍。其他脑区的cAMP水平未改变。仅涉及运动活动增加的应激源会使小脑cGMP增加。