Blass E M, Fitzgerald E
Department of Psychology, Johns Hopkins University, Baltimore, MD 21218.
Pharmacol Biochem Behav. 1988 Jan;29(1):9-13. doi: 10.1016/0091-3057(88)90266-3.
The effects of slow intraoral milk infusions on the opioid-mediated behaviors of ultrasonic vocalizations and paw removal from a hot plate (48-49 degrees C) were evaluated in 10-day-old rats. Milk reduced distress vocalization by circa 30% while increasing paw lift latencies by about 60%. Alterations in both behaviors were fully reversed by naltrexone (0.5 mg/kg) pretreatments. These data demonstrate the calming and analgesic effects of milk. Implications for a possible role of opioid peptides in mother-young relationships are discussed.
在10日龄大鼠中评估了经口腔缓慢输注牛奶对阿片类物质介导的超声波发声行为以及从热板（48 - 49摄氏度）上移开爪子行为的影响。牛奶使痛苦叫声减少了约30%，同时使爪子抬起潜伏期增加了约60%。纳曲酮（0.5毫克/千克）预处理可完全逆转这两种行为的变化。这些数据证明了牛奶的镇静和镇痛作用。讨论了阿片肽在母婴关系中可能发挥的作用。
