Yao Lie, Xie Zhi-Bo, Jin Chen, Jiang Yong-Jian, Li Ji, Yang Feng, Lin Quan-Jun, Fu De-Liang
Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Medicine (Baltimore). 2017 Mar;96(12):e6438. doi: 10.1097/MD.0000000000006438.
Pancreatic tumors rarely occur in adolescents, and the appropriateness of radical resection for these patients remains controversial.Medical records were retrospectively reviewed for patients younger than 19 years who underwent radical resection or limited resection (enucleation) between 2000 and 2015. Patient demographics, clinical characteristics, operative details, growth, and survival were analyzed.During the study period, 11 adolescents (mean age, 16.18 years; standard deviation, 1.99; interquartile range, 15.0-18.0) underwent radical resection (n = 7) or enucleation (n = 4) to treat solid pseudopapillary tumors (n = 5), pancreatic neuroendocrine tumors (n = 5), or pancreatic ductal adenocarcinoma (n = 1). None of the 7 patients who underwent radical resection experienced recurrence or serious complications, while 3 of 4 patients who underwent enucleation experienced recurrence (P = 0.02). Recurrence-free survival was slightly longer in patients who underwent radical resection, and this procedure did not appear to affect adolescent growth and development.Radical resection might be safe and effective for adolescents with pancreatic tumors.
胰腺肿瘤在青少年中很少见，对于这些患者进行根治性切除的合理性仍存在争议。对2000年至2015年间接受根治性切除或局限性切除（剜除术）的19岁以下患者的病历进行了回顾性分析。分析了患者的人口统计学特征、临床特征、手术细节、生长情况和生存率。在研究期间，11名青少年（平均年龄16.18岁；标准差1.99；四分位间距15.0 - 18.0）接受了根治性切除（n = 7）或剜除术（n = 4），以治疗实性假乳头状肿瘤（n = 5）、胰腺神经内分泌肿瘤（n = 5）或胰腺导管腺癌（n = 1）。7名接受根治性切除的患者均未出现复发或严重并发症，而4名接受剜除术的患者中有3名出现复发（P = 0.02）。接受根治性切除的患者无复发生存期略长，且该手术似乎并未影响青少年的生长发育。根治性切除对于患有胰腺肿瘤的青少年可能是安全有效的。
