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孕晚期与孕中期母体免疫后百日咳抗体向早产新生儿的转移

Pertussis Antibody Transfer to Preterm Neonates After Second- Versus Third-Trimester Maternal Immunization.

作者信息

Eberhardt Christiane S, Blanchard-Rohner Geraldine, Lemaître Barbara, Combescure Christophe, Othenin-Girard Véronique, Chilin Antonina, Petre Jean, Martinez de Tejada Begoña, Siegrist Claire-Anne

机构信息

Center for Vaccinology and Neonatal Immunology, Department of Pathology-Immunology, University of Geneva, Switzerland.

Department of Neonatology and Pediatric Intensive Care, Children's Hospital of Geneva, Switzerland.

出版信息

Clin Infect Dis. 2017 Apr 15;64(8):1129-1132. doi: 10.1093/cid/cix046.

DOI:10.1093/cid/cix046
PMID:28329335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5439344/
Abstract

Preterm infants are most vulnerable to pertussis. Whether they might benefit from maternal immunization is unknown. Extending our previous results in term neonates, this observational study demonstrates that second- rather than third-trimester maternal vaccination results in higher birth anti-pertussis toxin titers in preterm neonates.

摘要

早产儿最易感染百日咳。他们是否能从母体免疫中获益尚不清楚。扩展我们之前对足月儿的研究结果，这项观察性研究表明，孕中期而非孕晚期的母体疫苗接种会使早产儿出生时的抗百日咳毒素滴度更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/5439344/a5387dd97ebb/cix04601.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/5439344/a5387dd97ebb/cix04601.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ecc/5439344/a5387dd97ebb/cix04601.jpg

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Maternal Immunization Earlier in Pregnancy Maximizes Antibody Transfer and Expected Infant Seropositivity Against Pertussis.孕期早期进行母体免疫可使抗体转移最大化，并提高婴儿对百日咳的预期血清阳性率。
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