Ferreira Bárbara R, Vaz Ana S, Ramos Leonor, Reis José P, Gonçalo Margarida
Department of Dermatology, Coimbra Hospital and University Centre, Coimbra, Portugal.
Dermatol Online J. 2017 Feb 16;23(2):13030/qt1fg0f011.
A 4-month-old infant was observed with an acute itchy bullous dermatosis, predominantly involving the extremities, which revealed a dermal infiltrate rich in eosinophils, C3 deposits at the dermalepidermal junction, and circulating antibodies to BP180 antigen, confirming the diagnosis of bullous pemphigoid. He was initially treated with deflazacort 1 mg/kg/day, further increased to 2 mg/ kg/day, followed by reduction over seven weeks with complete clinical resolution within this period. We discuss epidemiology, etiology, relationship with vaccination, clinical features, and treatment of thisrelatively rare bullous dermatosis in the pediatric age.
一名4个月大的婴儿被观察到患有急性瘙痒性大疱性皮肤病，主要累及四肢，其表现为真皮层富含嗜酸性粒细胞浸润、真皮表皮交界处有C3沉积以及存在针对BP180抗原的循环抗体，从而确诊为大疱性类天疱疮。他最初接受地夫可特治疗，剂量为1毫克/千克/天，随后增至2毫克/千克/天，之后在7周内逐渐减量，在此期间临床症状完全缓解。我们讨论了这种儿科相对罕见的大疱性皮肤病的流行病学、病因、与疫苗接种的关系、临床特征及治疗方法。
