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婴儿期接种疫苗后发生大疱性类天疱疮：一例报告

Bullous Pemphigoid Onset Following Vaccination in Infancy: A Case Report.

作者信息

Hassanin Sondos, Katira Arnav, Hardcastle Nicola

机构信息

Dermatology, Sheffield Children's Hospital, Sheffield, GBR.

出版信息

Cureus. 2024 Dec 19;16(12):e76017. doi: 10.7759/cureus.76017. eCollection 2024 Dec.

DOI:10.7759/cureus.76017
PMID:39711925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11661878/
Abstract

Bullous pemphigoid (BP) is a rare autoimmune blistering disease characterised by autoantibodies against basal skin membrane antigens. Although the condition's aetiology remains unclear, recent cases have raised suspicions of an association with immunisation. In this study, we present a case of BP onset in a four-month-old infant following routine vaccination. The infant with BP responded well to systemic therapy. This case emphasises the requirement for further investigation into the potential link between BP and vaccination.

摘要

大疱性类天疱疮（BP）是一种罕见的自身免疫性水疱病，其特征是针对皮肤基底膜抗原产生自身抗体。尽管该病的病因尚不清楚，但最近的病例引发了人们对其与免疫接种之间关联的怀疑。在本研究中，我们报告了一例4个月大婴儿在常规疫苗接种后发生BP的病例。该患有BP的婴儿对全身治疗反应良好。本病例强调了进一步调查BP与疫苗接种之间潜在联系的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ab3/11661878/8804e28097ee/cureus-0016-00000076017-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ab3/11661878/748ba3be6213/cureus-0016-00000076017-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ab3/11661878/8804e28097ee/cureus-0016-00000076017-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ab3/11661878/748ba3be6213/cureus-0016-00000076017-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ab3/11661878/8804e28097ee/cureus-0016-00000076017-i02.jpg

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本文引用的文献

1
A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous Pemphigoid.一例婴儿中明显由脑膜炎球菌疫苗和轮状病毒疫苗引发的大疱性皮疹病例：聚焦婴儿型大疱性类天疱疮。
Dermatopathology (Basel). 2021 Feb 23;8(1):33-36. doi: 10.3390/dermatopathology8010006.
2
Bullous pemphigoid of infancy - report and review of infantile and pediatric bullous pemphigoid.婴儿大疱性类天疱疮——婴儿及儿童大疱性类天疱疮的报告与综述
Dermatol Online J. 2017 Feb 16;23(2):13030/qt1fg0f011.
3
Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial.
多西环素与泼尼松龙作为天疱疮初始治疗策略的比较：一项实用、非劣效性、随机对照试验。
Lancet. 2017 Apr 22;389(10079):1630-1638. doi: 10.1016/S0140-6736(17)30560-3. Epub 2017 Mar 6.
4
Three case reports of post immunization and post viral Bullous Pemphigoid: looking for the right trigger.免疫接种后和病毒感染后大疱性类天疱疮三例报告：探寻确切诱因
BMC Pediatr. 2017 Feb 23;17(1):60. doi: 10.1186/s12887-017-0813-0.
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Infantile Bullous Pemphigoid Following Vaccination.接种疫苗后发生的婴儿大疱性类天疱疮。
Indian Pediatr. 2016 May 8;53(5):425-6. doi: 10.1007/s13312-016-0867-3.
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Bullous pemphigoid in a 3-month-old infant: case report and literature review of this dermatosis in childhood.一名3个月大婴儿的大疱性类天疱疮：病例报告及儿童期该皮肤病的文献综述
An Bras Dermatol. 2013 Nov-Dec;88(6):961-5. doi: 10.1590/abd1806-4841.20132378.
7
[Infantile bullous pemphigoid].[婴儿大疱性类天疱疮]
Ann Dermatol Venereol. 2012 Aug-Sep;139(8-9):555-8. doi: 10.1016/j.annder.2012.05.011. Epub 2012 Jun 15.
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Bullous pemphigoid in infancy developing after the first vaccination.
Clin Exp Dermatol. 2010 Dec;35(8):940-1. doi: 10.1111/j.1365-2230.2010.03839.x.
9
Childhood bullous pemphigoid: clinical and immunological findings in a series of 4 cases.
Arch Dermatol. 2007 Feb;143(2):215-20. doi: 10.1001/archderm.143.2.215.