Rao N A, Romero J L, Fernandez M A, Sevanian A, Marak G E
Department of Ophthalmology, Estelle Doheny Eye Foundation, Los Angeles, California.
Surv Ophthalmol. 1987 Nov-Dec;32(3):209-13. doi: 10.1016/0039-6257(87)90096-8.
In acute inflammation, the tissue damage is generally mediated through polymorphonuclear leukocytes and macrophages. Recent studies on the mechanism of this leukocyte-mediated cytolysis have demonstrated that these cells, on stimulation, release a variety of reactive products. These metabolic products consist of superoxide and hydrogen peroxide, which in turn can form highly reactive species such as hydroxyl radicals. It is believed that these oxygen products play an important role in the tissue damage that occurs in inflammations such as uveitis. The ocular structures contain various antioxidant enzymes that normally protect against free radical mediated injury. In experimental animal models of uveitis, it has been shown that antioxidants and free radical scavengers can function as antiinflammatory agents and can protect the eye from inflammation-mediated tissue damage.
在急性炎症中，组织损伤通常是由多形核白细胞和巨噬细胞介导的。最近关于这种白细胞介导的细胞溶解机制的研究表明，这些细胞在受到刺激时会释放多种反应性产物。这些代谢产物包括超氧化物和过氧化氢，它们进而可以形成高反应性物质，如羟基自由基。据信，这些氧产物在葡萄膜炎等炎症中发生的组织损伤中起重要作用。眼部结构含有各种抗氧化酶，这些酶通常可防止自由基介导的损伤。在葡萄膜炎的实验动物模型中，已表明抗氧化剂和自由基清除剂可作为抗炎剂发挥作用，并可保护眼睛免受炎症介导的组织损伤。
