Jasim B, Sreelakshmi S, Mathew Jyothis, Radhakrishnan E K
School of Biosciences, Mahatma Gandhi University, PD Hills (PO), Kottayam, 686 560, Kerala, India.
Inter University Instrumentation Centre, Mahatma Gandhi University, PD Hills (PO), Kottayam, 686 560, Kerala, India.
3 Biotech. 2016 Dec;6(2):187. doi: 10.1007/s13205-016-0508-5. Epub 2016 Sep 1.
Biosynthetic adaptation of endophytic bacteria to chemically support host plant is very remarkable. Hence these organisms from medicinal plants are considered as highly valuable sources for natural products with diverse bioactivity. Their metabolite diversity and biosynthetic versatility have been increasingly explored for drug discovery. In this study, an endophytic Bacillus mojavensis with broad spectrum antibacterial properties has been analyzed for the chemical basis of its activity. By LC-MS/MS the organism was identified to have the biosynthetic ability to produce lipopeptides surfactin and fengycin. The impressive antibacterial activity of B. mojavensis as reported in the study indicates its broad antimicrobial applications.
内生细菌对宿主植物进行化学支持的生物合成适应性非常显著。因此，这些来自药用植物的生物体被认为是具有多种生物活性的天然产物的高价值来源。它们的代谢物多样性和生物合成多功能性在药物发现中得到了越来越多的探索。在本研究中，对具有广谱抗菌特性的内生莫哈韦芽孢杆菌的活性化学基础进行了分析。通过液相色谱-串联质谱法鉴定该生物体具有产生脂肽表面活性素和丰原素的生物合成能力。该研究报道的莫哈韦芽孢杆菌令人印象深刻的抗菌活性表明了其广泛的抗菌应用。
