Ataullakhanov F I, Vitvitskiĭ V M, Komarova S V, Mosharov E V
Biokhimiia. 1996 Feb;61(2):266-74.
Amphotericin B (1-3 mg/l) decreases the ATP content in erythrocytes by 11-26% and stimulates the K+ efflux but has no effect on the adenylate pool. Adenosine added to the erythrocyte suspension increases the adenylate pool, maintains a high intracellular ATP level for 6-8 hours of incubation at 37 degrees C and diminishes the amphotericin B-induced leakage of K+. Incubation of erythrocytes without glucose for 4-5 hours leads to a 20-50% loss of ATP accompanied by a significant reduction of the adenylate pool. Further addition of glucose partly restores the ATP level. In the presence of adenosine the ATP concentration is restored far more pronounced reaching nearly the original level due to the increase of the adenylate pool.
两性霉素B（1 - 3毫克/升）可使红细胞中的三磷酸腺苷（ATP）含量降低11 - 26%，并刺激钾离子外流，但对腺苷酸池无影响。向红细胞悬液中添加腺苷可增加腺苷酸池，在37℃孵育6 - 8小时期间维持较高的细胞内ATP水平，并减少两性霉素B诱导的钾离子泄漏。将红细胞在无葡萄糖的情况下孵育4 - 5小时会导致ATP损失20 - 50%，同时腺苷酸池显著减少。进一步添加葡萄糖可部分恢复ATP水平。在腺苷存在的情况下，由于腺苷酸池增加，ATP浓度恢复得更为显著，几乎达到原始水平。
