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免疫功能正常宿主发生的类圆线虫超感染综合征,导致出现杆状粒细胞血症并死亡。

Strongyloides hyperinfection syndrome in an immunocompetent host resulting in bandemia and death.

作者信息

Myint Aung, Chapman Courtney, Almira-Suarez Isabel, Mehta Nupur

机构信息

Department of Medicine, George Washington University, Washington, DC, USA.

Department of Pathology, George Washington University, Washington, DC, USA.

出版信息

BMJ Case Rep. 2017 Mar 22;2017:bcr2016217911. doi: 10.1136/bcr-2016-217911.

Abstract

infection is usually asymptomatic but can result in a hyperinfection syndrome, most commonly triggered by acquired or iatrogenic immunosuppression. Here, we present a case of a man aged 60 years originally from a strongyloides endemic area with a medical history of alcohol abuse who presents with strongyloides hyperinfection syndrome (SHS) complicated by partial small bowel obstruction, pulmonary haemorrhage, large bandemia without eosinophilia and cardiac arrest resulting in death. This case is notable for the presence of bandemia and absence of eosinophilia, lack of historical risk factors for hyperinfection, specifically corticosteroid immunosuppressants, and dramatic decline in clinical status which ultimately resulted in the patient's death. Clinicians should suspect SHS in immunocompetent patients who are from an endemic area and who have persistent gastrointestinal and/or pulmonary manifestations in the absence of a clear cause.

摘要

感染通常无症状,但可导致超感染综合征,最常见的诱因是获得性或医源性免疫抑制。在此,我们报告一例60岁男性病例,其原籍为类圆线虫流行地区,有酗酒病史,现患有类圆线虫超感染综合征(SHS),并发部分小肠梗阻、肺出血、无嗜酸性粒细胞增多的杆状核细胞增多症及心脏骤停,最终导致死亡。该病例的显著特点是存在杆状核细胞增多症而无嗜酸性粒细胞增多,缺乏超感染的既往危险因素,特别是皮质类固醇免疫抑制剂,以及临床状况急剧恶化最终导致患者死亡。临床医生应怀疑来自流行地区且在无明确病因情况下有持续胃肠道和/或肺部表现的免疫功能正常患者患有SHS。

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