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运动补偿及其对脑卒中后神经重组的影响。

Motor compensation and its effects on neural reorganization after stroke.

机构信息

Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Texas 78712, USA.

出版信息

Nat Rev Neurosci. 2017 May;18(5):267-280. doi: 10.1038/nrn.2017.26. Epub 2017 Mar 23.

Abstract

Stroke instigates a dynamic process of repair and remodelling of remaining neural circuits, and this process is shaped by behavioural experiences. The onset of motor disability simultaneously creates a powerful incentive to develop new, compensatory ways of performing daily activities. Compensatory movement strategies that are developed in response to motor impairments can be a dominant force in shaping post-stroke neural remodelling responses and can have mixed effects on functional outcome. The possibility of selectively harnessing the effects of compensatory behaviour on neural reorganization is still an insufficiently explored route for optimizing functional outcome after stroke.

摘要

中风引发了剩余神经回路修复和重塑的动态过程,而这个过程受到行为经验的影响。运动障碍的发生同时产生了一种强大的动力,促使患者发展新的、代偿性的日常活动方式。针对运动障碍而发展的代偿性运动策略是塑造中风后神经重塑反应的主要力量,并对功能结果产生混合影响。选择性利用代偿行为对神经重组的影响来优化中风后的功能结果,仍然是一条探索不足的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/520d/6289262/ec7ed9576799/nihms-912390-f0001.jpg

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