Sayyahfar Shirin, Lavasani Amin, Nateghian Alireza, Karimi Abdollah
Department of Pediatrics, Division of Pediatric Infectious Diseases, Iran University of Medical sciences, Tehran, Iran.
Pediatrician, Bahman Hospital, Zanjan, Iran.
Infect Chemother. 2017 Mar;49(1):44-50. doi: 10.3947/ic.2017.49.1.44. Epub 2017 Mar 13.
Acute Epstein-Barr virus (EBV) infection could lead to atherogenic lipid profile changes in adults; while there is no evidence about the children with Infectious mononucleosis (IM). The aim of this study was to evaluate the lipid profile of the children in acute phase of mononucleosis and two months after the recovery.
From 2010 through 2012, 36 children with IM aged 1-10 years were enrolled in a prospective cross-sectional study. Fasting serum total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), and triglyceride level were measured during acute phase of the disease and after 2 months of the recovery.
From 36 patients enrolled, 25 (69.4%) cases were male and the mean age of the patients was 4.1 ± 2.0 years. The mean of the total cholesterol level in the acute phase and 2 months after the recovery were149.5 ± 35.3 mg/dL and 145.7±30.6, respectively (P = 0.38). However, the serum level of HDL cholesterol in patients after 2 months of recovery was significantly increased (37.9 ± 9.3 mg/dL vs. 28.5 ± 10.6 mg/dL, P < 0.001). The mean value of serum LDL cholesterol was significantly reduced, two months after recovery (81.4 ± 19.5 mg/dL, vs. 92.6 ± 28.8 mg/dL, P = 0.009). Furthermore, the serum triglyceride level was significantly reduced after the recovery (108.7 ± 36.9 mg/dL) compared with the acute phase (163.8 ± 114.3 mg/dL) (P = 0.004).
EBV infection in children could change lipid profile which is partially restored 2 months after the recovery.
急性爱泼斯坦-巴尔病毒（EBV）感染可导致成人出现致动脉粥样硬化的血脂变化；而对于传染性单核细胞增多症（IM）患儿，尚无相关证据。本研究旨在评估单核细胞增多症急性期及恢复后两个月患儿的血脂情况。
2010年至2012年，36名年龄在1至10岁的IM患儿纳入一项前瞻性横断面研究。在疾病急性期及恢复2个月后测量空腹血清总胆固醇、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和甘油三酯水平。
在纳入的36例患者中，25例（69.4%）为男性，患者平均年龄为4.1±2.0岁。急性期及恢复后2个月的总胆固醇水平均值分别为149.5±35.3mg/dL和145.7±30.6mg/dL（P = 0.38）。然而，恢复2个月后患者的HDL胆固醇血清水平显著升高（37.9±9.3mg/dL对28.5±10.6mg/dL，P < 0.001）。恢复2个月后血清LDL胆固醇均值显著降低（81.4±19.5mg/dL对92.6±28.8mg/dL，P = 0.009）。此外，恢复后血清甘油三酯水平较急性期（163.8±114.3mg/dL）显著降低（108.7±36.9mg/dL）（P = 0.004）。
儿童EBV感染可改变血脂情况，恢复2个月后部分血脂情况得以恢复。
