Kanbay Mehmet, Gür Gürden, Yücel Muammer, Yilmaz Ugur, Boyacioğlu Sedat
Department of Internal Medicine, Baskent University Faculty of Medicine, Ankara, Turkey.
Dig Dis Sci. 2005 Jul;50(7):1228-31. doi: 10.1007/s10620-005-2764-9.
It is still unclear whether Helicobacter pylori infection is associated with risk factors for coronary artery disease. The aim of this study was to determine whether eradication of H. pylori infection affects serum lipid levels and C-reactive protein (CRP) levels. Seventy-eight patients who had H. pylori antigen positivity in their stools were enrolled. Clarithromycin, 1 g/day, amoxicillin, 2 g/day, and omeprazole, 40 mg/day, were given for 14 days. Serum total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), and CRP were measured at baseline and 8 weeks after therapy. According to H. pylori stool antigen study after 8 weeks, individuals in whom H. pylori was eradicated were recruited as group A and those in whom H. pylori was not eradicated formed group B. Group A comprised 57 patients, and group B 21 patients. Patients in group A comprised 32 women and 25 men and their ages ranged from 35 to 59 years. Patients in group B included 13 women and 8 men, aged 32-61 years. No significant difference in LDL, TC, or TG serum levels were found between group A and group B. Although CRP and HDL serum levels were found to be the same before and after treatment in group B, CRP levels were found to decrease and HDL levels to increase significantly in group A (P < 0.05). We conclude that H. pylori infection may affect lipid metabolism in a way that could increase the risk of atherosclerosis. Thus H. pylori infection is an independent risk factor for coronary artery disease.
幽门螺杆菌感染是否与冠状动脉疾病的危险因素相关仍不清楚。本研究的目的是确定根除幽门螺杆菌感染是否会影响血清脂质水平和C反应蛋白（CRP）水平。纳入了78例粪便幽门螺杆菌抗原呈阳性的患者。给予克拉霉素1g/天、阿莫西林2g/天和奥美拉唑40mg/天，持续14天。在基线和治疗8周后测量血清总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、甘油三酯（TG）和CRP。根据8周后的幽门螺杆菌粪便抗原研究，幽门螺杆菌被根除的个体被招募为A组，未被根除的个体形成B组。A组包括57例患者，B组包括21例患者。A组患者包括32名女性和25名男性，年龄在35至59岁之间。B组患者包括13名女性和8名男性，年龄在32至61岁之间。A组和B组之间的LDL、TC或TG血清水平没有显著差异。虽然B组治疗前后的CRP和HDL血清水平相同，但A组的CRP水平显著降低，HDL水平显著升高（P<0.05）。我们得出结论，幽门螺杆菌感染可能以增加动脉粥样硬化风险的方式影响脂质代谢。因此，幽门螺杆菌感染是冠状动脉疾病的独立危险因素。
