The fatty-acid-induced conformational states of human serum albumin investigated by means of multiple co-binding of protons and oleic acid.
作者信息
Dröge J H, Janssen L H, Wilting J
机构信息
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, State University of Utrecht, The Netherlands.
出版信息
Biochem J. 1988 Mar 1;250(2):443-6. doi: 10.1042/bj2500443.
Abstract
The binding of oleic acid to human serum albumin causes progressive changes in (a) the pK of some amino acid residues, as detected by pH-stat titration and (b) the induced molar ellipticities of albumin-bound drugs (diazepam and oxyphenbutazone), as measured by c.d. It is concluded that albumin undergoes several conformational transitions as the amount of oleic acid bound increases from 0 to about 9 molecules/molecule of protein. At least three different conformations of the protein seem to be involved. These conformations can be linked with the three classes of oleic acid-binding sites on albumin.
摘要
相似文献
1
The fatty-acid-induced conformational states of human serum albumin investigated by means of multiple co-binding of protons and oleic acid.
Biochem J. 1988 Mar 1;250(2):443-6. doi: 10.1042/bj2500443.
2
Evidence for the fatty acid-induced heterogeneity of the N and B conformations of human serum albumin.
Biochem Pharmacol. 1985 Sep 15;34(18):3299-304. doi: 10.1016/0006-2952(85)90349-1.
3
A study on the allosteric interaction between the major binding sites of human serum albumin using microcalorimetry.
Biochim Biophys Acta. 1985 Mar 1;827(3):396-402. doi: 10.1016/0167-4838(85)90224-9.
4
The effects of N-B transition of human serum albumin on the specific drug-binding sites.
Biochim Biophys Acta. 1982 Dec 20;709(2):247-55. doi: 10.1016/0167-4838(82)90467-8.
5
Circular dichroism studies on the inhibiting effect of oleic acid on the binding of diazepam to human serum albumin.
Biochem Pharmacol. 1977 Nov 15;26(22):2157-61. doi: 10.1016/0006-2952(77)90268-4.
6
The role of albumin conformation in the binding of diazepam to human serum albumin.
Biochim Biophys Acta. 1980 Dec 16;626(2):291-8. doi: 10.1016/0005-2795(80)90123-3.
7
Human serum albumin conformational changes as induced by tenoxicam and modified by simultaneous diazepam binding.
J Pharm Pharmacol. 1993 Dec;45(12):1050-3. doi: 10.1111/j.2042-7158.1993.tb07179.x.
8
The effects of oleic acid, tolbutamide, and oxyphenbutazone on the binding of warfarin by human serum albumin.
Res Commun Chem Pathol Pharmacol. 1979 Sep;25(3):577-84.
9
Evidence of human serum albumin beta-lactamase activity.
Biochem Mol Biol Int. 1994 Mar;32(4):789-95.
10
The pH dependence of the thermodynamics of the interaction of diazepam with human serum albumin.
J Biol Chem. 1985 Sep 25;260(21):11442-5.
引用本文的文献
1
Evaluation of the Interactions between Human Serum Albumin (HSA) and Non-Steroidal Anti-Inflammatory (NSAIDs) Drugs by Multiwavelength Molecular Fluorescence, Structural and Computational Analysis.
Pharmaceuticals (Basel). 2021 Mar 4;14(3):214. doi: 10.3390/ph14030214.
2
Native fluorescence and mag-indo-1-protein interaction as tools for probing unfolding and refolding sequences of the bovine serum albumin subdomain in the presence of guanidine hydrochloride.
J Protein Chem. 2000 Aug;19(6):431-9. doi: 10.1023/a:1026589012724.
3
Fluorescence behavior of tryptophan residues of bovine and human serum albumins in ionic surfactant solutions: a comparative study of the two and one tryptophan(s) of bovine and human albumins.
J Protein Chem. 1996 Apr;15(3):265-72. doi: 10.1007/BF01887115.
本文引用的文献
1
LINKED FUNCTIONS AND RECIPROCAL EFFECTS IN HEMOGLOBIN: A SECOND LOOK.
Adv Protein Chem. 1964;19:223-86. doi: 10.1016/s0065-3233(08)60190-4.
2
A structural transformation in bovine and human plasma albumins in alkaline solution as revealed by rotatory dispersion studies.
J Biol Chem. 1963 Jun;238:1984-8.
3
The effect of albumin conformation on the binding of warfarin to human serum albumin. The dependence of the binding of warfarin to human serum albumin on the hydrogen, calcium, and chloride ion concentrations as studied by circular dichroism, fluorescence, and equilibrium dialysis.
J Biol Chem. 1980 Apr 10;255(7):3032-7.
4
Human serum albumin as an allosteric two-state protein. Evidence from effects of calcium and warfarin on proton binding behaviour.
Biochim Biophys Acta. 1981 Jul 28;669(2):244-50. doi: 10.1016/0005-2795(81)90247-6.
5
The effect of chloride on the binding of warfarin to albumin as a function of pH.
Biochem Pharmacol. 1981 May 15;30(10):1025-31. doi: 10.1016/0006-2952(81)90437-8.
6
The role of albumin conformation in the binding of diazepam to human serum albumin.
Biochim Biophys Acta. 1980 Dec 16;626(2):291-8. doi: 10.1016/0005-2795(80)90123-3.
7
A comparative study of some physico-chemical properties of human serum albumin samples from different sources--I. Some physico-chemical properties of isoionic human serum albumin solutions.
Biochem Pharmacol. 1982 Dec 1;31(23):3775-9. doi: 10.1016/0006-2952(82)90292-1.
8
Molecular aspects of ligand binding to serum albumin.
Pharmacol Rev. 1981 Mar;33(1):17-53.
9
The location of drug binding sites in human serum albumin.
Biochem Pharmacol. 1981 Apr 1;30(7):687-92. doi: 10.1016/0006-2952(81)90151-9.
10
Allosteric properties of the oxyphenbutazone--human serum albumin complex.
Pharm Weekbl Sci. 1983 Oct 21;5(5):228-33. doi: 10.1007/BF02332949.
Zotero 插件