Ciavattini Andrea, Delli Carpini Giovanni, Moriconi Lorenzo, Clemente Nicolò, Orici Francesca, Boschi Anna Chiara, Montik Nina, Mazzanti Laura
a Woman's Health Sciences Department, Gynecologic Section and.
b Department of Clinical Sciences, Biochemistry Section , Polytechnic University of Marche , Ancona , Italy.
Gynecol Endocrinol. 2017 Aug;33(8):634-637. doi: 10.1080/09513590.2017.1302418. Epub 2017 Mar 23.
Uterine fibroids are the most common neoplasm of the genital tract in reproductive women. Obesity holds a role as risk factor for uterine fibroids, through hormonal and inflammatory mechanisms. Visceral fat is a hormonally active tissue, so an increase in visceral fat may be considered as a risk factor, through the increased production of inflammatory mediators. The aim of the study was, therefore, to evaluate the association between the presence of uterine fibroids and fat tissue distribution, and to assess the efficacy of both anthropometric and instrumental indicators, in particular the sonographic measurement of preperitoneal fat thickness (PFT) and subcutaneous fat thickness (SFT). Study group consisted of childbearing-age women with at least one uterine fibroid with a diameter ≥10 mm (n = 71), all the childbearing-age women who access to the outpatient service of our institution in the same period, without evidence of uterine fibroids, constituted the control group (n = 145). A significantly difference in BMI (p = 0.0034), PFT (p < 0.0001), and SFT (p = 0.0003) emerged. At the multivariate analysis, only PFT showed an independent significant association with the presence of uterine fibroids (p < 0.0001). The ROC curve analysis identified a cut-off value of 6.7 mm of PFT as discriminator for the presence of uterine fibroids.
子宫肌瘤是育龄期女性生殖道最常见的肿瘤。肥胖通过激素和炎症机制成为子宫肌瘤的危险因素。内脏脂肪是一种具有激素活性的组织，因此内脏脂肪增加可能被视为危险因素，这是由于炎症介质产生增加所致。因此，本研究的目的是评估子宫肌瘤的存在与脂肪组织分布之间的关联，并评估人体测量指标和仪器指标的有效性，特别是腹膜前脂肪厚度（PFT）和皮下脂肪厚度（SFT）的超声测量。研究组由至少有一个直径≥10毫米子宫肌瘤的育龄期女性组成（n = 71），同期所有到本机构门诊就诊且无子宫肌瘤证据的育龄期女性构成对照组（n = 145）。BMI（p = 0.0034）、PFT（p < 0.0001）和SFT（p = 0.0003）出现显著差异。在多变量分析中，只有PFT显示与子宫肌瘤的存在有独立的显著关联（p < 0.0001）。ROC曲线分析确定PFT为6.7毫米作为子宫肌瘤存在的判别临界值。
