Muawad Reema, Dabbagh Rufaidah, Sabr Yasser
Master in Public Health - Field Epidemiology, Family and Community Medicine Department, King Saud University, Riyadh, KSA.
Family and Community Medicine Department, College of Medicine, King Saud University, Riyadh, KSA.
J Taibah Univ Med Sci. 2022 Jul 11;17(6):1039-1046. doi: 10.1016/j.jtumed.2022.06.005. eCollection 2022 Dec.
The objective of this study was to measure the association between uterine fibroids (UFs) and several risk factors (parity, miscarriage, diabetes, hypertension, physical activity, smoking, family history of UF and contraceptive pill use) among Saudi women.
A case-control study was conducted in 478 women at two medical centers in Riyadh. Cases were confirmed by ultrasound. Demographic and risk factor information was collected from interviews and medical records. The prevalence of risk factors was calculated with 95% confidence interval (CI). Unconditional logistic regression analysis was used to measure the associations between UFs and the risk factors.
More than half the participants were obese. The average body mass index (BMI) was 31.2 (±6.81) for cases and 29.4 (±7.02) for controls. Women 40 years or older had four times the odds of UFs than women younger than 40 years (adjusted odds ratio [AOR] = 4.24, 95% CI = 2.63, 6.85). Having a family history of UFs was associated with 69% greater odds of UFs (AOR = 1.69, 95% CI = 1.02, 2.81). Being obese was associated with 74% greater odds of UFs (AOR = 1.74, 95% CI = 1.00, 2.59), whereas previous live births decreased the odds of UFs by 62% (AOR = 0.38, 95% CI = 0.19, 0.75).
This study identified risk factors associated with UFs in the Saudi population. Age over 40 years, obesity and a family history of UFs are important risk factors for UF, whereas parity appears to be protective against UF development in Saudi women. Early recognition of these risk factors is important to prevent UF complications.
本研究的目的是衡量沙特女性子宫肌瘤（UFs）与几种风险因素（产次、流产、糖尿病、高血压、体育活动、吸烟、子宫肌瘤家族史和避孕药使用情况）之间的关联。
在利雅得的两个医疗中心对478名女性进行了一项病例对照研究。通过超声确诊病例。从访谈和医疗记录中收集人口统计学和风险因素信息。计算风险因素的患病率及95%置信区间（CI）。采用无条件逻辑回归分析来衡量子宫肌瘤与风险因素之间的关联。
超过一半的参与者肥胖。病例组的平均体重指数（BMI）为31.2（±6.81），对照组为29.4（±7.02）。40岁及以上的女性患子宫肌瘤的几率是40岁以下女性的四倍（调整优势比[AOR]=4.24，95%CI=2.63，6.85）。有子宫肌瘤家族史与患子宫肌瘤的几率高69%相关（AOR=1.69，95%CI=1.02，2.81）。肥胖与患子宫肌瘤的几率高74%相关（AOR=1.74，95%CI=1.00，2.59），而既往活产使患子宫肌瘤的几率降低62%（AOR=0.38，95%CI=0.19，0.75）。
本研究确定了沙特人群中与子宫肌瘤相关的风险因素。40岁以上、肥胖和子宫肌瘤家族史是子宫肌瘤的重要风险因素，而产次似乎对沙特女性子宫肌瘤的发生有保护作用。早期识别这些风险因素对于预防子宫肌瘤并发症很重要。
