Nulianti Rina, Lubis Syahnural, Madjid Tita Husnitawati, Permadi Wiryawan, Adriansyah Putri Nadhira Adinda, Nisa Aisyah Shofiatun
Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
Department of Obstetrics and Gynecology, Anugerah Bunda Khatulistiwa Hospital- Morula IVF, Pontianak, Indonesia.
Int Med Case Rep J. 2025 Jul 8;18:859-867. doi: 10.2147/IMCRJ.S527318. eCollection 2025.
Premature ovarian insufficiency (POI) leads to the early loss of ovarian function before age 40, resulting in infertility and hormonal imbalance. Despite the use of assisted reproductive technologies (ART), success rates remain low in this population. Platelet-rich plasma (PRP) therapy is emerging as a potential adjunct to enhance ovarian reserve.
CASE ILLUSTRATIONCASE 1: A 25-year-old nulliparous woman with a history of ectopic pregnancy and an anti-Müllerian hormone (AMH) level below 1 ng/mL received two PRP injections scheduled between days 7 to 12 of her cycle. After the first injection, her AMH level remained <0.5 ng/mL. Following the second PRP injection, her AMH level increased to >0.5 ng/mL. A frozen embryo transfer resulted in a successful term pregnancy and healthy newborn.
CASE 2: A 36-year-old nulliparous woman, married for seven years, also presented POI and AMH levels <1 ng/mL followed the same PRP and IVF protocol. After two PRP sessions, her AMH levels improved similarly to Case 1. Despite an initial pregnancy, the patient experienced pregnancy loss.
These findings suggest that PRP may improve ovarian response in women with POI undergoing IVF. Further studies are warranted.
卵巢早衰（POI）导致40岁之前卵巢功能过早丧失，从而引发不孕和激素失衡。尽管使用了辅助生殖技术（ART），但该人群的成功率仍然较低。富血小板血浆（PRP）疗法正在成为增强卵巢储备的一种潜在辅助手段。
病例说明
病例1：一名25岁未生育女性，有宫外孕病史，抗苗勒管激素（AMH）水平低于1 ng/mL，在其月经周期的第7至12天接受了两次PRP注射。第一次注射后，她的AMH水平仍<0.5 ng/mL。第二次PRP注射后，她的AMH水平升至>0.5 ng/mL。一次冻融胚胎移植导致足月妊娠并产下健康新生儿。
病例2：一名36岁未生育女性，结婚7年，也出现了POI且AMH水平<1 ng/mL，遵循相同的PRP和体外受精方案。经过两次PRP治疗后，她的AMH水平与病例1相似得到改善。尽管最初怀孕，但患者经历了流产。
这些发现表明，PRP可能改善接受体外受精的POI女性的卵巢反应。有必要进行进一步研究。
