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褪黑素对肝脏损伤和疾病的影响。

Effects of Melatonin on Liver Injuries and Diseases.

作者信息

Zhang Jiao-Jiao, Meng Xiao, Li Ya, Zhou Yue, Xu Dong-Ping, Li Sha, Li Hua-Bin

机构信息

Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.

School of Chinese Medicine, The University of Hong Kong, Hong Kong 999077, China.

出版信息

Int J Mol Sci. 2017 Mar 23;18(4):673. doi: 10.3390/ijms18040673.

DOI:10.3390/ijms18040673
PMID:28333073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5412268/
Abstract

Liver injuries and diseases are serious health problems worldwide. Various factors, such as chemical pollutants, drugs, and alcohol, could induce liver injuries. Liver diseases involve a wide range of liver pathologies, including hepatic steatosis, fatty liver, hepatitis, fibrosis, cirrhosis, and hepatocarcinoma. Despite all the studies performed up to now, therapy choices for liver injuries and diseases are very few. Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries and diseases remains a priority. Melatonin is a well-known natural antioxidant, and has many bioactivities. There are numerous studies investigating the effects of melatonin on liver injuries and diseases, and melatonin could regulate various molecular pathways, such as inflammation, proliferation, apoptosis, metastasis, and autophagy in different pathophysiological situations. Melatonin could be used for preventing and treating liver injuries and diseases. Herein, we conduct a review summarizing the potential roles of melatonin in liver injuries and diseases, paying special attention to the mechanisms of action.

摘要

肝脏损伤和疾病是全球范围内严重的健康问题。化学污染物、药物和酒精等多种因素可诱发肝脏损伤。肝脏疾病涉及广泛的肝脏病理，包括肝脂肪变性、脂肪肝、肝炎、纤维化、肝硬化和肝癌。尽管迄今为止已经进行了所有这些研究，但针对肝脏损伤和疾病的治疗选择却非常少。因此，寻找一种能够安全有效地阻断或逆转肝脏损伤和疾病的新疗法仍然是当务之急。褪黑素是一种著名的天然抗氧化剂，具有多种生物活性。有许多研究调查了褪黑素对肝脏损伤和疾病的影响，并且褪黑素可以在不同的病理生理情况下调节各种分子途径，如炎症、增殖、凋亡、转移和自噬。褪黑素可用于预防和治疗肝脏损伤和疾病。在此，我们进行综述，总结褪黑素在肝脏损伤和疾病中的潜在作用，并特别关注其作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/5412268/47765782b40a/ijms-18-00673-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/5412268/42b34b70a269/ijms-18-00673-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/5412268/dcde2f9c35a2/ijms-18-00673-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/5412268/47765782b40a/ijms-18-00673-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/5412268/42b34b70a269/ijms-18-00673-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/5412268/dcde2f9c35a2/ijms-18-00673-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29a7/5412268/47765782b40a/ijms-18-00673-g003.jpg

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