Kjaer S K, de Villiers E M, Haugaard B J, Christensen R B, Teisen C, Møller K A, Poll P, Jensen H, Vestergaard B F, Lynge E
Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen.
Int J Cancer. 1988 Apr 15;41(4):518-24. doi: 10.1002/ijc.2910410408.
In Greenland, the incidence of cervical cancer is 5.7 times higher than in Denmark among women aged 20-39. From Nuuk (Greenland) and Nykøbing Falster (Denmark) a sample of 800 women aged 20-39 years was drawn at random. A total of 586 and 661 women were investigated in Greenland and Denmark respectively. All women had a gynecological examination including a PAP-smear and cervical scrape for HPV-analysis (filter in situ hybridization). A blood sample was taken for analysis of HSV type-specific antibodies (ELISA). The percentage of normal smears was identical in the 2 areas (95%). The total HPV 16/18 infection rate was 13% in Denmark and 8.8% in Greenland, and the age-adjusted prevalence rate in Greenland was only 67% of that in Denmark (95% CI: 0.05-0.89). The proportion of HPV 6/11 positivity was the same in Greenland and in Denmark (6.7% vs. 7.5%). A significantly higher proportion of the Greenlandic women had HSV-2 antibodies (68.2%) in comparison with Danish women (30.9%) (p less than 0.01). The prevalence of HSV-1 was also higher in Greenland, especially in women aged 20 to 24. Our finding of a higher HPV infection rate in Denmark than in Greenland, opposed to cervical cancer rates, does not support a role for these viruses as determinants of cervical cancer incidence. In contrast, the rate of HSV-2 infection co-varies with the observed incidence of cervical cancer. This is in line with the notion that differences in cervical cancer incidence between Denmark and Greenland are determined by aspects of sexual behavior.
在格陵兰岛，20至39岁女性的宫颈癌发病率比丹麦高5.7倍。从努克（格陵兰岛）和尼科宾法尔斯特（丹麦）随机抽取了800名20至39岁的女性样本。格陵兰岛和丹麦分别对586名和661名女性进行了调查。所有女性都接受了妇科检查，包括巴氏涂片检查和宫颈刮片以进行HPV分析（原位杂交检测）。采集血样以分析HSV型特异性抗体（酶联免疫吸附测定）。两个地区正常涂片的比例相同（95%）。丹麦HPV 16/18总感染率为13%，格陵兰岛为8.8%，格陵兰岛经年龄调整后的患病率仅为丹麦的67%（95%置信区间：0.05 - 0.89）。格陵兰岛和丹麦HPV 6/11阳性比例相同（6.7%对7.5%）。与丹麦女性（30.9%）相比，格陵兰岛女性中HSV - 2抗体阳性比例显著更高（68.2%）（p小于0.01）。格陵兰岛HSV - 1的患病率也更高，尤其是在20至24岁的女性中。我们发现丹麦的HPV感染率高于格陵兰岛，这与宫颈癌发病率相反，并不支持这些病毒作为宫颈癌发病率决定因素的作用。相比之下，HSV - 2感染率与观察到的宫颈癌发病率共同变化。这与丹麦和格陵兰岛之间宫颈癌发病率差异由性行为方面决定的观点一致。
