Eskin T A, Merigan W H, Wood R W
Department of Pathology and Laboratory Medicine and Neurology, University of Rochester School of Medicine and Dentistry, NY 14642.
Invest Ophthalmol Vis Sci. 1988 Apr;29(4):519-27.
We examined the morphological effects of carbon disulfide exposure on neurons and vasculature of the visual system of macaque monkeys. Five monkeys were exposed to 256 ppm carbon disulfide (CS2) by inhalation for 6 hr a day, 5 days a week. One monkey, sacrificed immediately after exposure, had numerous axonal swellings in the distal optic tract. Four other monkeys survived the exposure period for at least 1 year and were found to have suffered marked degeneration of central retinal ganglion cells, with little or no effect on other neurons in the retina. No evidence was found for arteriosclerotic or aneurysmal changes, suggesting that visual system injury in primates induced by carbon disulfide exposure is not dependent on the occurrence of structural changes in retinal blood vessels.
我们研究了二硫化碳暴露对猕猴视觉系统神经元和脉管系统的形态学影响。五只猴子每天吸入256 ppm二硫化碳（CS2），每周5天，每天6小时。一只猴子在暴露后立即处死，其视束远端有许多轴突肿胀。另外四只猴子在暴露期存活至少1年，发现其视网膜中央神经节细胞发生明显退化，而对视网膜中的其他神经元几乎没有影响。未发现动脉硬化或动脉瘤样改变的证据，这表明二硫化碳暴露诱导的灵长类动物视觉系统损伤不依赖于视网膜血管结构变化的发生。
