尼日利亚埃努古市学龄期感染艾滋病毒儿童的神经认知功能

Neurocognitive Function of School-aged HIV-infected Children in Enugu, Nigeria.

作者信息

Iloh Kenechukwu K, Emodi Ifeoma J, Ibeziako Ngozi S, Ikefuna Anthony N, Ubesie Agozie C, Iloh Ogochukwu N, Ilechukwu Gideon C, Ayuk Adaeze C

机构信息

Department of Paediatrics, University of Nigeria Enugu Campus, Enugu 400001, Nigeria.

Department of Paediatrics, University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu 400001, Nigeria.

出版信息

J Trop Pediatr. 2017 Dec 1;63(6):425-430. doi: 10.1093/tropej/fmx006.

DOI:10.1093/tropej/fmx006

PMID:28334859

Abstract

BACKGROUND

Evidence has shown neurocognitive problems often exist among human immunodeficiency virus (HIV)-infected children. There are limited data for children in Nigeria.

METHODS

This was a cross-sectional study of 100 school-aged perinatally HIV-infected children seen in the paediatric HIV clinic and age/sex-matched controls from the general paediatric clinic. Neuro-cognitive functioning was assessed using the Raven's progressive matrices (RPM) that has been adapted for the Nigerian population.

RESULTS

The mean RPM score of subjects was 22.97 ± 11.35 compared with 32.93 ± 15.71 among controls (p < 0.001). Twenty-two percent of subjects in the HIV-infected group vs. 56% of controls were in the above-average intelligence group on the RPM. Thirty-four percent had average scores, while 22% were in the below-average scoring range. Neuro-cognitive functioning of the subjects was significantly affected by immunologic staging and socio-economic status.

CONCLUSIONS

Neurocognitive functioning of the HIV-infected children was significantly lower than those of their un-infected counterparts. Neurodevelopmental evaluation should be part of standard care in HIV-infected children in Nigerian setting.

摘要

背景

有证据表明，感染人类免疫缺陷病毒（HIV）的儿童常常存在神经认知问题。在尼日利亚，针对儿童的相关数据有限。

方法

这是一项横断面研究，研究对象为100名在儿科HIV诊所就诊的围产期感染HIV的学龄儿童，以及来自普通儿科诊所的年龄/性别匹配的对照组儿童。使用针对尼日利亚人群改编的瑞文渐进性矩阵（RPM）评估神经认知功能。

结果

研究对象的平均RPM得分为22.97±11.35，而对照组为32.93±15.71（p<0.001）。在RPM测试中，HIV感染组22%的研究对象属于智力高于平均水平的群体，而对照组这一比例为56%。34%的研究对象得分处于平均水平，22%处于低于平均水平的得分区间。研究对象的神经认知功能受到免疫分期和社会经济地位的显著影响。