Jiang Bingqian, Qu Huihua, Kong Hui, Zhang Yue, Liu Shuchen, Cheng Jinjun, Yan Xin, Zhao Yan
School of Basic Medical Sciences, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China.
Institute of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, Beijing 100029, China.
Molecules. 2017 Mar 21;22(3):498. doi: 10.3390/molecules22030498.
The effect of sweet foods, such as honey, was investigated from the perspective of pharmacokinetics on the absorption of glycyrrhizic acid (GA). Due to the unique properties of indirect competitive enzyme-linked immunosorbent assay (icELISA), namely, its: specificity, sensitivity, repeatability, simple pretreatment of samples, fast and simple operation, and because it is economic and non-polluting, it has received increased attention. In this study, we used the advantages of this method to see how honey affected the pharmacokinetics of GA. The effects of honey on the pharmacokinetics of GA by ELISA were investigated for the first time. The results indicate that honey can postpone the peak concentration of GA in mouse blood, and this effect correlates well with fructose. As a representative of sweet foods, the result provides the valuable information that honey, or fructose, may act as sustained-releasing drugs in clinical scenarios; and that sweet foods may have some influences on drugs when taken together.
从药代动力学角度研究了蜂蜜等甜食对甘草酸（GA）吸收的影响。由于间接竞争酶联免疫吸附测定法（icELISA）具有特异性、灵敏度、重复性、样品预处理简单、操作快速简便、经济且无污染等独特性质，它受到了越来越多的关注。在本研究中，我们利用该方法的优势来观察蜂蜜如何影响GA的药代动力学。首次通过酶联免疫吸附测定法研究了蜂蜜对GA药代动力学的影响。结果表明，蜂蜜可以推迟GA在小鼠血液中的峰值浓度，且这种作用与果糖密切相关。作为甜食的代表，该结果提供了有价值的信息，即蜂蜜或果糖在临床情况下可能起到缓释药物的作用；并且甜食与药物同时服用时可能会对药物产生一些影响。
