Joshi Deepmala, Mittal Deepak Kumar, Shukla Sangeeta, Srivastav Sunil Kumar, Dixit Vaibhav A
Reproductive Biology and Toxicology Laboratory, UNESCO Satellite Center of Trace Element Research & School of Studies in Zoology, Jiwaji University, Gwalior, Madhya Pradesh, India; Department of Zoology, DDU Gorakhpur University, Gorakhpur, Uttar Pradesh, India.
Reproductive Biology and Toxicology Laboratory, UNESCO Satellite Center of Trace Element Research & School of Studies in Zoology, Jiwaji University, Gwalior, Madhya Pradesh, India.
Exp Toxicol Pathol. 2017 Jul 5;69(6):373-382. doi: 10.1016/j.etp.2017.02.009. Epub 2017 Mar 21.
The present investigation has been conducted to evaluate the therapeutic potential of Curcuma longa (200mgkg, po) and curcumin (80mgkg, po) for their hepatoprotective efficacy against mercuric chloride (HgCl: 12μmolkg, ip; once only) hepatotoxicity. The HgCl administration altered various biochemical parameters, including transaminases, alkaline phosphatase, lactate dehydrogenase, bilirubin, gamma-glutamyl transferase, triglycerides and cholesterol contents with a concomitant decline in protein and albumin concentration in serum which were restored towards control by therapy of Curcuma longa or curcumin. On the other hand, both treatments showed a protective effect on drug metabolizing enzymes viz. aniline hydroxylase (AH) and amidopyrine-N-demethylase (AND), hexobarbitone induced sleep time and BSP retention. Choleretic, 1,1-diphenyl-2-picryl-hydrazil (DPPH)-free radical scavenging activities and histological studies also supported the biochemical findings. The present study concludes that Curcuma longa extract or curcumin has the ability to alleviate the hepatotoxic effects caused by HgCl in rats.
本研究旨在评估姜黄（200mg/kg，口服）和姜黄素（80mg/kg，口服）对氯化汞（HgCl：12μmol/kg，腹腔注射；仅一次）肝毒性的肝保护疗效。给予HgCl会改变各种生化参数，包括转氨酶、碱性磷酸酶、乳酸脱氢酶、胆红素、γ-谷氨酰转移酶、甘油三酯和胆固醇含量，同时血清中的蛋白质和白蛋白浓度下降，而通过姜黄或姜黄素治疗可使其恢复至对照水平。另一方面，两种治疗方法对药物代谢酶即苯胺羟化酶（AH）和氨基比林-N-脱甲基酶（AND）、己巴比妥诱导睡眠时间和BSP潴留均有保护作用。利胆、1,1-二苯基-2-苦基肼基自由基清除活性和组织学研究也支持了生化研究结果。本研究得出结论，姜黄提取物或姜黄素具有减轻大鼠HgCl所致肝毒性作用的能力。
