Mohamad Ragaa Hosny, El-Bastawesy Amal Mohamad, Zekry Zekry Khalid, Al-Mehdar Hussain A, Al-Said Mohamad Gamil Abdel Monaam, Aly Soaad Shaker, Sharawy Sabry Mohamed, El-Merzabani Mahmuod M
Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
J Med Food. 2009 Apr;12(2):394-402. doi: 10.1089/jmf.2007.0715.
The major component, called curcumin, of turmeric (Curcuma longa L.) (Family Zingiberaceae) powder is responsible for its biological actions. The present study aimed to prove the protective effect of turmeric extract against doxorubicin (DOX)-induced cardiac, hepatic, and renal toxicity as evaluated in rats. Body weight and urine volume of the animal groups under investigation were recorded daily throughout the experimental period. Also, the cardiac, hepatic, and renal toxicities were determined by estimating the changes in serum activities of the enzymes lactate dehydrogenase (LDH) and creatine kinase (CK), serum levels of alanine aminotransferase, aspartate aminotransferase, nitric oxide, albumin, and calcium, and kidney and liver tissue activities of superoxide dismutase and glutathione peroxidase, as well as the contents of glutathione and malondialdehyde. Hyperlipidemia was also determined, and protein and albumin changes in urine were estimated. Biochemical and histopathological findings demonstrate that turmeric extract has multiple therapeutic activities that are beneficially protective, and it has an ameliorative effect against DOX-induced cardiac toxicity and hepatotoxicity and blocks DOX-induced nephrosis. Similarly, turmeric extract inhibited the DOX-induced increase in plasma cholesterol, LDH, and CK. The present findings conclude that the turmeric extract has multiple therapeutic activities that block the cardiac, hepatic, and renal toxicities induced by DOX, and it also possibly acts as a free radical scavenger.
姜黄（姜科，姜黄属植物姜黄Curcuma longa L.）粉的主要成分姜黄素是其具有生物学活性的原因所在。本研究旨在证实姜黄提取物对阿霉素（DOX）诱导的大鼠心脏、肝脏和肾脏毒性具有保护作用。在整个实验期间，每天记录受试动物组的体重和尿量。此外，通过评估乳酸脱氢酶（LDH）和肌酸激酶（CK）的血清活性变化、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、一氧化氮、白蛋白和钙的血清水平，以及超氧化物歧化酶和谷胱甘肽过氧化物酶的肾脏和肝脏组织活性，以及谷胱甘肽和丙二醛的含量，来确定心脏、肝脏和肾脏毒性。还测定了高脂血症情况，并评估了尿液中的蛋白质和白蛋白变化。生化和组织病理学结果表明，姜黄提取物具有多种有益的治疗活性，对DOX诱导的心脏毒性和肝毒性具有改善作用，并可阻止DOX诱导的肾病。同样，姜黄提取物抑制了DOX诱导的血浆胆固醇、LDH和CK升高。本研究结果表明，姜黄提取物具有多种治疗活性，可阻止DOX诱导的心脏、肝脏和肾脏毒性，并且它还可能作为自由基清除剂发挥作用。
