Taniyama K, Suzuki H, Yamada A, Tahara E
Dept. of Pathology, Shizuoka General Hospital.
Gan No Rinsho. 1988 Mar;34(3):379-84.
A 67-year-old woman with extramammary Paget's disease of the buttocks is reported. She manifested an eczematous skin lesion of both sides of the buttock and had an intradermal tumor of the right side. Resected specimens revealed widely spreading Paget's cells (15.5 X 15 cm), an intraepidermal adenocarcinoma (1 X 0.6 cm) in the eczematous epidermis, and an intradermal mucinous adenocarcinoma (3.3 X 2 X 2.5 cm). The intraepidermal adenocarcinoma was located just above the intradermal mucinous adenocarcinoma. From the histological localization of these lesions, and the electron microscopical findings of the Paget's cells and the intraepidermal adenocarcinoma, this case was thought to have started as an intraepidermal adenocarcinoma, which might have originated from the intraepidermal eccrine gland.
报告了一名67岁患有臀部乳房外佩吉特病的女性。她表现为双侧臀部湿疹样皮肤病变，右侧有一个皮内肿瘤。切除标本显示佩吉特细胞广泛扩散（15.5×15厘米），湿疹样表皮中有一个表皮内腺癌（1×0.6厘米），以及一个皮内黏液腺癌（3.3×2×2.5厘米）。表皮内腺癌位于皮内黏液腺癌的正上方。根据这些病变的组织学定位以及佩吉特细胞和表皮内腺癌的电子显微镜检查结果，该病例被认为始于表皮内腺癌，其可能起源于表皮内的小汗腺。
