Bálint Anita, Berényi Anna, Farkas Klaudia, Pallagi Kunstár Éva, Altorjay Ábel, Csonka Andrea, Krizsán Mária, Szűcs Mónika, Pál Attila, Fábián Anna, Bor Renáta, Milassin Ágnes, Szulcsán Ádám, Mariann Rutka, Szepes Zoltán, Molnár Tamás
Department of Medicine, University of Szeged, Szeged, Hungary.
Turk J Gastroenterol. 2017 May;28(3):171-175. doi: 10.5152/tjg.2017.16711. Epub 2017 Mar 23.
BACKGROUND/AIMS: Noninvasive activity markers are extremely important in conditions, such as pregnancy, when endoscopy is not recommended. The aim of this prospective study was to determine fecal calprotectin (FC) concentrations in healthy non-pregnant and pregnant women and in patients with inflammatory bowel disease (IBD).
Healthy pregnant and non-pregnant women and patients with active and inactive IBD were prospectively enrolled in this study. Demographic and clinical parameters and clinical disease activity scores in patients with IBD were recorded. Blood and stool samples of every patient were obtained to determine C-reactive protein and FC levels. FC levels were measured with a quantitative lateral flow assay.
One hundred and thirty-five subjects were enrolled in the study (24 non-pregnant and 48 pregnant healthy women, 40 non-pregnant patients with active IBD and 23 non-pregnant patients with inactive IBD). FC was significantly higher in active IBD patients than in pregnant (p<0.001) and non-pregnant healthy women (p<0.001). No difference could be detected in FC concentrations between pregnant and non-pregnant healthy women.
Since FC levels remained unchanged during pregnancy, it may be a useful noninvasive diagnostic tool in pregnancy for monitoring mucosal inflammation.
背景/目的：在诸如妊娠等不建议进行内镜检查的情况下，非侵入性活动标志物极为重要。本前瞻性研究的目的是确定健康非妊娠和妊娠女性以及炎症性肠病（IBD）患者的粪便钙卫蛋白（FC）浓度。
前瞻性纳入健康妊娠和非妊娠女性以及活动期和非活动期IBD患者。记录IBD患者的人口统计学和临床参数以及临床疾病活动评分。采集每位患者的血液和粪便样本以测定C反应蛋白和FC水平。采用定量侧向流动分析法测量FC水平。
135名受试者纳入研究（24名非妊娠健康女性、48名妊娠健康女性、40名活动期非妊娠IBD患者和23名非活动期非妊娠IBD患者）。活动期IBD患者的FC显著高于妊娠健康女性（p<0.001）和非妊娠健康女性（p<0.001）。妊娠健康女性和非妊娠健康女性之间的FC浓度未检测到差异。
由于FC水平在妊娠期间保持不变，它可能是妊娠期间监测黏膜炎症的一种有用的非侵入性诊断工具。
