Mangels Daniel R, Mohler Emile R
From the Hospital of the University of Pennsylvania, Department of Medicine, Philadelphia (D.R.M.); and Perelman School of Medicine at the University of Pennsylvania, Department of Medicine, Cardiovascular Division, Section of Vascular Medicine, Philadelphia (E.R.M.).
Arterioscler Thromb Vasc Biol. 2017 May;37(5):757-763. doi: 10.1161/ATVBAHA.117.309048. Epub 2017 Mar 23.
The impact of diet on cardiovascular disease has become an increasingly relevant topic as ongoing epidemiological evidence continues to demonstrate clear associations with disease burden and mortality. Certain diets, such as those high in sodium and saturated fat, are associated with cardiovascular disease states, while other diets can be cardioprotective. However, there is limited knowledge on how the micro- and macronutrients within such cardioprotective diets afford their benefits. One such micronutrient is the catechin class, which are naturally occurring compounds in plant foods, such as teas, cocoa, wine, pears, and apples. Recent evidence reveals that catechins may be a key mediator in cardiovascular health via mechanisms of blood pressure reduction, flow-mediated vasodilation, and atherosclerosis attenuation. This review evaluates the current literature on the interplay between catechins and cardiovascular disease, which may have important implications for nutrition counseling and pharmaceutical drug development.
随着流行病学证据不断表明饮食与疾病负担和死亡率之间存在明确关联，饮食对心血管疾病的影响已成为一个越来越重要的话题。某些饮食，如高钠和饱和脂肪饮食，与心血管疾病状态相关，而其他饮食则可能具有心脏保护作用。然而，对于这些具有心脏保护作用的饮食中的微量和宏量营养素如何发挥其益处，人们了解有限。儿茶素类就是这样一种微量营养素，它是植物性食物中的天然化合物，如茶、可可、葡萄酒、梨和苹果。最近的证据表明，儿茶素可能是心血管健康的关键调节因子，其作用机制包括降低血压、血流介导的血管舒张和减轻动脉粥样硬化。本综述评估了当前关于儿茶素与心血管疾病相互作用的文献，这可能对营养咨询和药物开发具有重要意义。
