Spritz R A, Giebel L B
Department of Medical Genetics and Pediatrics, University of Wisconsin--Madison 53706.
Mol Biol Evol. 1988 Jan;5(1):21-9. doi: 10.1093/oxfordjournals.molbev.a040474.
We have isolated the delta-globin gene of the New-World spider monkey, Ateles geoffroyi, and compared its nucleotide sequence with those of other primate delta- and beta-globin genes. Among primate delta-globin genes, the rate of nonsynonymous substitutions is much less than the rate of synonymous substitutions. This suggests that primate delta-globin genes may remain under evolutionary conservation, perhaps because hemoglobin A2 has an as yet unknown physiological importance.
我们分离出了新世界蜘蛛猴（Ateles geoffroyi）的δ-珠蛋白基因，并将其核苷酸序列与其他灵长类动物的δ-珠蛋白基因和β-珠蛋白基因的序列进行了比较。在灵长类动物的δ-珠蛋白基因中，非同义替换率远低于同义替换率。这表明灵长类动物的δ-珠蛋白基因可能仍处于进化保守状态，也许是因为血红蛋白A2具有尚未明确的生理重要性。
